MedKoo Cat#: 564587 | Name: 360A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

360A is a stabilizing G-Quadruplex ligand which has potent selectivity toward G-quadruplex structures of the telomeric 3'-overhang.

Chemical Structure

360A
360A
CAS#794458-56-3

Theoretical Analysis

MedKoo Cat#: 564587

Name: 360A

CAS#: 794458-56-3

Chemical Formula: C27H23I2N5O2

Exact Mass: 0.0000

Molecular Weight: 703.32

Elemental Analysis: C, 46.11; H, 3.30; I, 36.09; N, 9.96; O, 4.55

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Related CAS #
No Data
Synonym
360-A; 360A; 360 A
IUPAC/Chemical Name
3,3'-((pyridine-2,6-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium) iodide; (2,6-N,N′-Methyl-quinolinio-3-yl)-pyridine dicarboxamide
InChi Key
CYDYPTJPHHNFEL-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H21N5O2.2HI/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21;;/h3-17H,1-2H3;2*1H
SMILES Code
O=C(NC1=CC(C=CC=C2)=C2[N+](C)=C1)C3=NC(C(NC4=C[N+](C)=C(C=CC=C5)C5=C4)=O)=CC=C3.[I-].[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 703.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pennarun G, Granotier C, Hoffschir F, Mandine E, Biard D, Gauthier LR, Boussin FD. Role of ATM in the telomere response to the G-quadruplex ligand 360A. Nucleic Acids Res. 2008 Mar;36(5):1741-54. doi: 10.1093/nar/gkn026. Epub 2008 Feb 7. PubMed PMID: 18263609; PubMed Central PMCID: PMC2275132. 2: Gauthier LR, Granotier C, Hoffschir F, Etienne O, Ayouaz A, Desmaze C, Mailliet P, Biard DS, Boussin FD. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69(4):629-40. doi: 10.1007/s00018-011-0767-6. Epub 2011 Jul 20. PubMed PMID: 21773671; PubMed Central PMCID: PMC3265728.