MedKoo Cat#: 558382 | Name: NSC-670224

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-670224 is a histone deacetylases-6 (HDAC6) inhibitor and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug

Chemical Structure

NSC-670224
NSC-670224
CAS#1374648-47-1

Theoretical Analysis

MedKoo Cat#: 558382

Name: NSC-670224

CAS#: 1374648-47-1

Chemical Formula: C21H34Cl3NO

Exact Mass:

Molecular Weight: 422.86

Elemental Analysis: C, 59.65; H, 8.10; Cl, 25.15; N, 3.31; O, 3.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NSC-670224; NSC 670224; NSC670224;
IUPAC/Chemical Name
cis-{2-[4-tert-Butyl-1-(2,4-dichloro-benzyl)-cyclohexyloxy]-ethyl}-dimethyl-amine hydrochloride
InChi Key
FSIBYCVOFLVKGN-COQUQOPOSA-N
InChi Code
InChI=1S/C21H33Cl2NO.ClH/c1-20(2,3)17-8-10-21(11-9-17,25-13-12-24(4)5)15-16-6-7-18(22)14-19(16)23;/h6-7,14,17H,8-13,15H2,1-5H3;1H/t17-,21+;
SMILES Code
CN(CCO[C@@]1(CC2=CC=C(Cl)C=C2Cl)CC[C@@H](C(C)(C)C)CC1)C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 422.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zuckerman NB, Myers AS, Quan TK, Bray WM, Lokey RS, Hartzog GA, Konopelski JP. Structural determination of NSC 670224, synthesis of analogues and biological evaluation. ChemMedChem. 2012 May;7(5):761-5. doi: 10.1002/cmdc.201200038. Epub 2012 Feb 29. PubMed PMID: 22378491; PubMed Central PMCID: PMC3516922.