Namirotene | CAS#101506-83-6 | retinoid

MedKoo Cat#: 584357 | Name: Namirotene

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Namirotene is a synthetic retinoic acid analog seen to be effective in the treatment of keratoconjunctivitis sicca (KCS) in rabbit.

Chemical Structure

Namirotene

CAS#101506-83-6

Theoretical Analysis

MedKoo Cat#: 584357

Name: Namirotene

CAS#: 101506-83-6

Chemical Formula: C17H18O2S

Exact Mass: 286.1028

Molecular Weight: 286.39

Elemental Analysis: C, 71.30; H, 6.34; O, 11.17; S, 11.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Namirotene; CBS 211A; Cbs 211 A

IUPAC/Chemical Name

Benzoic acid, 4-(2-(5-(1-methylethyl)-2-thienyl)-1-propenyl)-, (E)-

InChi Key

GDDUESKGWJTHLR-ZRDIBKRKSA-N

InChi Code

InChI=1S/C17H18O2S/c1-11(2)15-8-9-16(20-15)12(3)10-13-4-6-14(7-5-13)17(18)19/h4-11H,1-3H3,(H,18,19)/b12-10+

SMILES Code

O=C(O)C1=CC=C(/C=C(C2=CC=C(C(C)C)S2)\C)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 286.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Taimi M, Defacque H, Commes T, Favero J, Dornand J, Marti J. The retinoic acid analog CBS-211A potentiates the 1 alpha,25-dihydroxyvitamin D3-induced differentiation of U937 cells. Agents Actions. 1993 Jan;38(1-2):91-9. PubMed PMID: 8480542. 2: Driot JY, Bonne C. Beneficial effects of a retinoic acid analog, CBS-211 A, on an experimental model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 1992 Jan;33(1):190-5. PubMed PMID: 1730541. 3: Roussillon S, Bonne C, Coquelet C, Tournoux A. Quantitative parameters of a high-affinity binding site for retinoic acid in corneal endothelial cells. Cornea. 1986;5(3):145-9. PubMed PMID: 2980830. 4: Bonne C, Junquero D, Driot JY, Coquelet C, Modat G. [Effect of retinoids on the growth of corneal endothelial cells in culture]. Ophtalmologie. 1990 Jan-Feb;4(1):84-7. French. PubMed PMID: 2250947. 5: Junquéro D, Modat G, Coquelet C, Bonne C. Retinoid-induced potentiation of epidermal growth factor mitogenic effect on corneal endothelial cells. Cornea. 1990 Jan;9(1):41-4. PubMed PMID: 2297993. 6: Junquéro D, Modat G, Coquelet C, Bonne C. Retinoids enhance the number of EGF receptors in corneal endothelial cells. Exp Eye Res. 1990 Jul;51(1):49-53. PubMed PMID: 2373180.