SHR2554, also known as EZH2-IN-15, is a potent EZH2 inhibitor that shows broad-spectrum anti-tumor efficacy in preclinical studies., SHR2554 inhibited proliferation and induced G1 phase arrest in EZH2-mutant DLBCL cell lines. The combination of EZH2 inhibitor SHR2554 with histone deacetylase (HDAC) inhibitor chidamide (hereafter referred to as HBI8000) exerted synergistic anti-proliferative activity in vitro and in vivo. Gene expression profile analysis revealed dramatic inhibition of the DNA replication process in combined treatment.
MedKoo Cat#: 207209
Name: SHR2554
CAS#: 2098545-98-1
Chemical Formula: C32H44N4O4
Exact Mass: 548.3363
Molecular Weight: 548.73
Elemental Analysis: C, 70.04; H, 8.08; N, 10.21; O, 11.66
The following data is based on the product molecular weight 548.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
