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MedKoo Cat#: 126106 | Name: Isomolpan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ISOMOLPAN is a selective D3/D2 receptor agonist.

Chemical Structure

Isomolpan
Isomolpan
CAS#107320-86-5 (free base)

Theoretical Analysis

MedKoo Cat#: 126106

Name: Isomolpan

CAS#: 107320-86-5 (free base)

Chemical Formula: C15H21NO2

Exact Mass: 247.1572

Molecular Weight: 247.34

Elemental Analysis: C, 72.84; H, 8.56; N, 5.66; O, 12.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
100745-12-8 (HCl) 107320-86-5 (free base)
Synonym
Isomolpan; (4aR,10bS)-4-propyl-1,2,3,4a,5,10b-hexahydrochromeno[3,4-b]pyridin-9-ol;
IUPAC/Chemical Name
(4aR,10bS)-4-propyl-1,3,4,4a,5,10b-hexahydro-2H-chromeno[3,4-b]pyridin-9-ol
InChi Key
GSLWRDKYYIQKIM-JSGCOSHPSA-N
InChi Code
InChI=1S/C15H21NO2/c1-2-7-16-8-3-4-12-13-9-11(17)5-6-15(13)18-10-14(12)16/h5-6,9,12,14,17H,2-4,7-8,10H2,1H3/t12-,14-/m0/s1
SMILES Code
OC1=CC=C2C([C@]3([C@@]([H])(N(CCC3)CCC)CO2)[H])=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 247.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Altar CA, Berner B, Beall P, Carlsen SF, Boyar WC. Dopamine release and metabolism after chronic delivery of selective or nonselective dopamine autoreceptor agonists. Mol Pharmacol. 1988 Jun;33(6):690-5. PMID: 3380082. 2: Liebman JM, Gerber R, Hall NR, Altar CA. Heterogeneous rotational responsiveness in 6-hydroxydopamine-denervated rats: pharmacological and neurochemical characterization. Psychopharmacology (Berl). 1988;96(4):477-83. doi: 10.1007/BF02180027. PMID: 3149769. 3: Gobert A, Rivet JM, Audinot V, Cistarelli L, Spedding M, Vian J, Peglion JL, Millan MJ. Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: II. Both D2 and "silent" D3 autoreceptors control synthesis and release in mesolimbic, mesocortical and nigrostriatal pathways. J Pharmacol Exp Ther. 1995 Nov;275(2):899-913. PMID: 7473181. 4: Millan MJ, Peglion JL, Vian J, Rivet JM, Brocco M, Gobert A, Newman-Tancredi A, Dacquet C, Bervoets K, Girardon S, et al. Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy. J Pharmacol Exp Ther. 1995 Nov;275(2):885-98. PMID: 7473180. 5: Altar CA, Boyar WC, Wood PL. Dopamine autoreceptor agonists including CGS 15855A decrease dopamine release and metabolism in mouse brain. Eur J Pharmacol. 1987 Feb 24;134(3):303-11. doi: 10.1016/0014-2999(87)90361-x. PMID: 3569417. 6: Altar CA, Boyar WC, Oei E, Wood PL. Dopamine autoreceptors modulate the in vivo release of dopamine in the frontal, cingulate and entorhinal cortices. J Pharmacol Exp Ther. 1987 Jul;242(1):115-20. PMID: 3612520. 7: Iyengar S, Hausler A, Kim HS, Marien M, Altar CA, Wood PL. The dopamine autoreceptor agonist, (+/-)-trans-1,3,4,4a5,10b-hexahydro-4-propyl-2H [1]benzopyrano [3,4-b] pyridin-9-ol hydrochloride (CGS 15855A), modulates striatal dopamine metabolism and prolactin release. Neuropharmacology. 1989 Jan;28(1):27-31. doi: 10.1016/0028-3908(89)90063-4. PMID: 2522597. 8: Gobert A, Rivet JM, Audinot V, Newman-Tancredi A, Cistarelli L, Millan MJ. Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release. Neuroscience. 1998 May;84(2):413-29. doi: 10.1016/s0306-4522(97)00565-4. PMID: 9539213. 9: Boyar WC, Altar CA. Modulation of in vivo dopamine release by D2 but not D1 receptor agonists and antagonists. J Neurochem. 1987 Mar;48(3):824-31. doi: 10.1111/j.1471-4159.1987.tb05591.x. PMID: 2949060. 10: Lasley SM. Regulation of dopaminergic activity, but not tyrosine hydroxylase, is diminished after chronic inorganic lead exposure. Neurotoxicology. 1992 Fall;13(3):625-35. PMID: 1361980.

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