MedKoo Cat#: 126099 | Name: Vevorisertib trihydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vevorisertib is an antineoplastic. Vevorisertib is an AKT inhibitor.

Chemical Structure

Vevorisertib trihydrochloride
Vevorisertib trihydrochloride
CAS#1416775-08-0 (3HCl)

Theoretical Analysis

MedKoo Cat#: 126099

Name: Vevorisertib trihydrochloride

CAS#: 1416775-08-0 (3HCl)

Chemical Formula: C35H41Cl3N8O

Exact Mass: 694.2469

Molecular Weight: 696.12

Elemental Analysis: C, 60.39; H, 5.94; Cl, 15.28; N, 16.10; O, 2.30

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 2,050.00 2 Weeks
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Synonym
Vevorisertib (trihydrochloride); Vevorisertib trihydrochloride; ARQ 751 (trihydrochloride); ARQ751; ARQ-751; ARQ 751; Vevorisertib
IUPAC/Chemical Name
N-(1-(3-(3-(4-(1-aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)piperidin-4-yl)-N-methylacetamide trihydrochloride
InChi Key
HNFNJTGXAZHZSB-UHFFFAOYSA-N
InChi Code
InChI=1S/C35H38N8O.3ClH/c1-23(44)41(2)26-15-20-42(21-16-26)28-7-3-6-24(22-28)30-13-14-31-34(39-30)43(33(40-31)29-8-4-19-38-32(29)36)27-11-9-25(10-12-27)35(37)17-5-18-35;;;/h3-4,6-14,19,22,26H,5,15-18,20-21,37H2,1-2H3,(H2,36,38);3*1H
SMILES Code
CC(=O)N(C)C1CCN(CC1)C2=CC=CC(=C2)C3=NC4=C(C=C3)N=C(N4C5=CC=C(C=C5)C6(CCC6)N)C7=C(N=CC=C7)N.Cl.Cl.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 696.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kurma K, Zeybek Kuyucu A, Roth GS, Sturm N, Mercey-Ressejac M, Abbadessa G, Yu Y, Lerat H, Marche PN, Decaens T, Macek Jilkova Z. Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model. Int J Mol Sci. 2022 Dec 19;23(24):16206. doi: 10.3390/ijms232416206. PMID: 36555845; PMCID: PMC9784348. 2: Pant S, Hamilton E, Ulahannan SV, Strauss JF, Braiteh FS, Huang M, Liaw DCH. Phase 1b study of pan-AKT inhibitor vevorisertib alone or with paclitaxel or fulvestrant in PIK3CA/AKT/PTEN-mutated advanced solid tumors. Cancer. 2023 Jun 15;129(12):1919-1929. doi: 10.1002/cncr.34733. Epub 2023 Mar 27. PMID: 36970876.