Synonym
Befuraline hydrochloride; Befuraline HCl; Befuraline; DIV-154; DIV 154; DIV154;
IUPAC/Chemical Name
benzofuran-2-yl(4-benzylpiperazin-1-yl)methanone hydrochloride
InChi Key
GMEYXHHLZUAKDY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H20N2O2.ClH/c23-20(19-14-17-8-4-5-9-18(17)24-19)22-12-10-21(11-13-22)15-16-6-2-1-3-7-16;/h1-9,14H,10-13,15H2;1H
SMILES Code
Cl.O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC4=C(O3)C=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
356.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Boksay IJ, Popendiker K, Weber RO, Söder A. Synthesis and pharmacological activity of befuraline (N-benzo[b]furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound. Arzneimittelforschung. 1979;29(2):193-204. PMID: 582130.
2: Gastpar M, Gastpar G, Gilsdorf U. Befuraline, its safety and efficacy in depressed inpatients. Pharmacopsychiatry. 1985 Nov;18(6):351-5. doi: 10.1055/s-2007-1017396. PMID: 4089015.
3: Clemens R, Clemens U. Offener Versuch mit Befuraline (DIV 154) bei 64 depressiv Kranken [Open study of befuraline (DIV 154) in 64 depressive patients (author's transl)]. Arzneimittelforschung. 1977;27(12):2416-21. German. PMID: 341906.
4: Valdman AV, Avdulov NA, Rozganets VV, Rusacov DY. Behavioural and neurochemical studies of the action of atypical antidepressants. Acta Physiol Pharmacol Bulg. 1983;9(3):3-10. PMID: 6142583.
5: Younes-El-Hage S, Labssita Y, Baziard-Mouysset G, Payard M, Caignard DH, Rubat C. Synthèse et étude de l'activité antidépressive d'aryl et hétéroaryl carboxamides de la benzylpipérazine [Synthesis and antidepressive activity study of aryl and heteroaryl carboxamides of benzylpiperazine]. Ann Pharm Fr. 2000 Jul;58(4):254-9. French. PMID: 10915973.
6: Rozhanets VV, Rusakov DIu, Val'dman AV. Izuchenie afinnosti razlichnykh antidepressantov k imipraminovym retseptoram sinapticheskikh membran golovnogo mozga myshi [Affinity of various antidepressive agents to imipramine receptors of synaptic membranes in mouse brain]. Biull Eksp Biol Med. 1982 Oct;94(10):42-3. Russian. PMID: 6293607.
7: Avdulov NA, Maĭsov NI. Atipichnye antidepressanty: vliianie na sinaptosomal'nyĭ zakhvat serotonina i GAMK [Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]. Biull Eksp Biol Med. 1981 Nov;92(11):564-6. Russian. PMID: 7198493.
8: Rusakov DIu, Val'dman AV. Primenenie plavatel'nogo testa dlia vyiavleniia antidepressivnoĭ aktivnosti pri odnokratnom i khronicheskom vvedenii veshchestv [Use of the swimming test for demonstrating antidepressive activity of drugs during single and repeated administration]. Farmakol Toksikol. 1983 Sep- Oct;46(5):107-11. Russian. PMID: 6226535.
9: Komarek J, Neumann FJ. The cardiovascular activity of a new antidepressant DIV 154 in comparison with imipramine. Arzneimittelforschung. 1977;27(11):2066-70. PMID: 580001.
10: Avdulov NA, Zaslavskiĭ BIu, Mikheeva LM, Val'dman AV. Sopostavlenie membranotropnosti i otnositel'noĭ gidrofobnosti antidepressantov razlichnykh khimicheskikh grupp [Comparison of membranotropic and relative hydrophobic properties of antidepressants with different chemical structure]. Biull Eksp Biol Med. 1982 Sep;94(9):66-7. Russian. PMID: 7171827.
11: Avdulov NA, Dobretsov GE, Val'dman AV. Korreliatsiia mezhdu srodstovm antidepressantov k membranam i ikh vliianiem na obratnyĭ zakhvat neĭromediatorov [Correlation between antidepressant membrane affinity and their effects on neuromediator reuptake]. Biull Eksp Biol Med. 1981 Aug;92(8):44-6. Russian. PMID: 7295965.
