Befuraline | CAS#41717-30-0

MedKoo Cat#: 535286 | Name: Befuraline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Befuraline, also known as DIV-154, is a psychoactive drug and member of the piperazine chemical class which was developed in Germany in the 1970s. Befuraline has stimulant and antidepressant effects and has seen some use in Germany and France, although it has never become widely used. Befuraline's active metabolite benzylpiperazine is responsible for its effects.

Chemical Structure

Befuraline

CAS#41717-30-0 (free base)

Theoretical Analysis

MedKoo Cat#: 535286

Name: Befuraline

CAS#: 41717-30-0 (free base)

Chemical Formula: C20H20N2O2

Exact Mass: 320.1525

Molecular Weight: 320.39

Elemental Analysis: C, 74.98; H, 6.29; N, 8.74; O, 9.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

41716-84-1 (HCl) 41717-30-0 (free base)

Synonym

Befuraline; DIV-154; DIV 154; DIV154;

IUPAC/Chemical Name

1-(2-Benzofuranylcarbonyl)-4-benzylpiperazine

InChi Key

SRIJFPBZWUFLFD-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H20N2O2/c23-20(19-14-17-8-4-5-9-18(17)24-19)22-12-10-21(11-13-22)15-16-6-2-1-3-7-16/h1-9,14H,10-13,15H2

SMILES Code

O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC4=CC=CC=C4O3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 320.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Boksay IJ, Popendiker K, Weber RO, Söder A. Synthesis and pharmacological activity of befuraline (N-benzo[b]furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound. Arzneimittelforschung. 1979;29(2):193-204. PMID: 582130. 2: Gastpar M, Gastpar G, Gilsdorf U. Befuraline, its safety and efficacy in depressed inpatients. Pharmacopsychiatry. 1985 Nov;18(6):351-5. doi: 10.1055/s-2007-1017396. PMID: 4089015. 3: Clemens R, Clemens U. Offener Versuch mit Befuraline (DIV 154) bei 64 depressiv Kranken [Open study of befuraline (DIV 154) in 64 depressive patients (author's transl)]. Arzneimittelforschung. 1977;27(12):2416-21. German. PMID: 341906. 4: Valdman AV, Avdulov NA, Rozganets VV, Rusacov DY. Behavioural and neurochemical studies of the action of atypical antidepressants. Acta Physiol Pharmacol Bulg. 1983;9(3):3-10. PMID: 6142583. 5: Younes-El-Hage S, Labssita Y, Baziard-Mouysset G, Payard M, Caignard DH, Rubat C. Synthèse et étude de l'activité antidépressive d'aryl et hétéroaryl carboxamides de la benzylpipérazine [Synthesis and antidepressive activity study of aryl and heteroaryl carboxamides of benzylpiperazine]. Ann Pharm Fr. 2000 Jul;58(4):254-9. French. PMID: 10915973. 6: Rozhanets VV, Rusakov DIu, Val'dman AV. Izuchenie afinnosti razlichnykh antidepressantov k imipraminovym retseptoram sinapticheskikh membran golovnogo mozga myshi [Affinity of various antidepressive agents to imipramine receptors of synaptic membranes in mouse brain]. Biull Eksp Biol Med. 1982 Oct;94(10):42-3. Russian. PMID: 6293607. 7: Avdulov NA, Maĭsov NI. Atipichnye antidepressanty: vliianie na sinaptosomal'nyĭ zakhvat serotonina i GAMK [Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]. Biull Eksp Biol Med. 1981 Nov;92(11):564-6. Russian. PMID: 7198493. 8: Rusakov DIu, Val'dman AV. Primenenie plavatel'nogo testa dlia vyiavleniia antidepressivnoĭ aktivnosti pri odnokratnom i khronicheskom vvedenii veshchestv [Use of the swimming test for demonstrating antidepressive activity of drugs during single and repeated administration]. Farmakol Toksikol. 1983 Sep- Oct;46(5):107-11. Russian. PMID: 6226535. 9: Komarek J, Neumann FJ. The cardiovascular activity of a new antidepressant DIV 154 in comparison with imipramine. Arzneimittelforschung. 1977;27(11):2066-70. PMID: 580001. 10: Avdulov NA, Zaslavskiĭ BIu, Mikheeva LM, Val'dman AV. Sopostavlenie membranotropnosti i otnositel'noĭ gidrofobnosti antidepressantov razlichnykh khimicheskikh grupp [Comparison of membranotropic and relative hydrophobic properties of antidepressants with different chemical structure]. Biull Eksp Biol Med. 1982 Sep;94(9):66-7. Russian. PMID: 7171827. 11: Avdulov NA, Dobretsov GE, Val'dman AV. Korreliatsiia mezhdu srodstovm antidepressantov k membranam i ikh vliianiem na obratnyĭ zakhvat neĭromediatorov [Correlation between antidepressant membrane affinity and their effects on neuromediator reuptake]. Biull Eksp Biol Med. 1981 Aug;92(8):44-6. Russian. PMID: 7295965.