TH 9619 disodium | MTHFD2 Inhibitor | MTHFD1 Inhibitor

MedKoo Cat#: 126065 | Name: TH 9619 disodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2, and selectively kills cancer cells. TH9619 targets nuclear MTHFD2 but does not inhibit mitochondrial MTHFD2. TH9619 inhibits the activity of MTHFD1 occurring downstream of mitochondrial formate release, leading to the accumulation of 10-formyl-tetrahydrofolate.

Chemical Structure

TH 9619 disodium

CAS#TH9619 disodium

Theoretical Analysis

MedKoo Cat#: 126065

Name: TH 9619 disodium

CAS#: TH9619 disodium

Chemical Formula: C17H16FN7Na2O7

Exact Mass: 495.0891

Molecular Weight: 495.33

Elemental Analysis: C, 41.22; H, 3.26; F, 3.84; N, 19.79; Na, 9.28; O, 22.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2379556-22-4 (free acid) TH9619 disodium

Synonym

TH 9619 disodium; TH9619 disodium; TH-9619 disodium; TH 9619; TH-9619; TH9619

IUPAC/Chemical Name

sodium (5-(2-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)acetamido)-3-fluoropicolinoyl)-L-glutamate

InChi Key

AKIUEXPYEGJOLL-WWPIYYJJSA-L

InChi Code

InChI=1S/C17H18FN7O7.2Na/c18-8-3-6(22-10(26)4-7-13(19)24-17(20)25-14(7)29)5-21-12(8)15(30)23-9(16(31)32)1-2-11(27)28;;/h3,5,9H,1-2,4H2,(H,22,26)(H,23,30)(H,27,28)(H,31,32)(H5,19,20,24,25,29);;/q;2*+1/p-2/t9-;;/m0../s1

SMILES Code

NC1=NC(C(CC(NC2=CN=C(C(F)=C2)C(N[C@H](C(O[Na])=O)CCC(O[Na])=O)=O)=O)=C(N1)N)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 495.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3. PMID: 37012496; PMCID: PMC10132981. 2. Bonagas, N., Gustafsson, N.M.S., Henriksson, M. et al. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer 3, 156–172 (2022). https://doi.org/10.1038/s43018-022-00331-y