ZL-40 is a PDE4 Inhibitor (IC50 = 37.4 nM) for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases. ZL40 showed a remarkable oral bioavailability (F = 94%), satisfactory safety, and a lower emetogenic potency than the approved PDE4 inhibitors roflumilast and apremilast. Encouragingly, ZL40 exhibited AUD therapeutic effects by decreasing alcohol intake and improving acute alcohol-induced sedation and motor impairment. Meanwhile, ZL40 displayed the potential to alleviate alcoholic liver injury and attenuate inflammation in the NIAAA mice model.
MedKoo Cat#: 125897
Name: ZL40
CAS#: N/A
Chemical Formula: C12H14ClN3O3
Exact Mass: 283.0724
Molecular Weight: 283.71
Elemental Analysis: C, 50.80; H, 4.97; Cl, 12.50; N, 14.81; O, 16.92
The following data is based on the product molecular weight 283.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
