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MedKoo Cat#: 125768 | Name: A-7669662

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A7669662 is an AMPK activator.

Chemical Structure

A-7669662
A-7669662
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125768

Name: A-7669662

CAS#: N/A

Chemical Formula: C20H12N2O3S

Exact Mass: 360.0600

Molecular Weight: 360.39

Elemental Analysis: C, 66.66; H, 3.36; N, 7.77; O, 13.32; S, 8.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
A-7669662; A7669662; A 7669662
IUPAC/Chemical Name
4-hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
InChi Key
CTESJDQKVOEUOY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
SMILES Code
OC1=C(C2=CC=C(C3=CSC(N4)=C3C(O)=C(C#N)C4=O)C=C2)C=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators Simon J. Shaw, Dane A. Goff, Luke A. Boralsky, Rajinder Singh, David J. Sweeny, Gary Park, Tian-Qiang Sun, Yonchu Jenkins, Vadim Markovtsov, Sarkiz D. Issakani, Donald G. Payan, and Yasumichi Hitoshi Journal of Medicinal Chemistry Article ASAP DOI: 10.1021/acs.jmedchem.3c01983 2. Rodríguez C, Contreras C, Sáenz-Medina J, Muñoz M, Corbacho C, Carballido J, García-Sacristán A, Hernandez M, López M, Rivera L, Prieto D. Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation. Redox Biol. 2020 Jul;34:101575. doi: 10.1016/j.redox.2020.101575. Epub 2020 May 16. PMID: 32470915; PMCID: PMC7256643.