Sapanisertib, also known as TAK-228, MLN0128 and INK128, is a TORC1/2 inhibitor, is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.
MedKoo Cat#: 125706
Name: Sapanisertib monophosphate
CAS#: 1422006-47-0 (monophosphate)
Chemical Formula: C15H18N7O5P
Exact Mass: 407.1100
Molecular Weight: 407.33
Elemental Analysis: C, 44.23; H, 4.45; N, 24.07; O, 19.64; P, 7.60
The following data is based on the product molecular weight 407.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
