PT-88 is a highly potent and kinase selective mTOR inhibitor. PT-88 demonstrated an mTOR inhibitory IC50 value of 1.2 nM without obvious inhibition against another 195 kinases from the kinase profiling screening. PT-88 displayed selective inhibition against MCF-7 cells (IC50: 0.74 μM) with high biosafety against normal cells, in which autophagy induced by mTOR inhibition was implicated.
MedKoo Cat#: 126850
Name: PT-88
CAS#: N/A
Chemical Formula: C30H31N7O5
Exact Mass: 569.2387
Molecular Weight: 569.62
Elemental Analysis: C, 63.26; H, 5.49; N, 17.21; O, 14.04
The following data is based on the product molecular weight 569.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
