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MedKoo Cat#: 125643 | Name: PB-94

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PB-94 is a HDAC11inhibitor.

Chemical Structure

PB-94
PB-94
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125643

Name: PB-94

CAS#: N/A

Chemical Formula: C29H33N3O4

Exact Mass: 487.2500

Molecular Weight: 487.60

Elemental Analysis: C, 71.44; H, 6.82; N, 8.62; O, 13.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PB-94; PB94; PB 94
IUPAC/Chemical Name
N-(((3r,5r,7r)-adamantan-1-yl)methyl)-1-(4-(hydroxycarbamoyl)-3-methoxybenzyl)-1H-indole-5-carboxamide
InChi Key
JJMWRKOHPNUEJN-CTZVOZSRSA-N
InChi Code
InChI=1S/C29H33N3O4/c1-36-26-11-18(2-4-24(26)28(34)31-35)16-32-7-6-22-12-23(3-5-25(22)32)27(33)30-17-29-13-19-8-20(14-29)10-21(9-19)15-29/h2-7,11-12,19-21,35H,8-10,13-17H2,1H3,(H,30,33)(H,31,34)/t19-,20+,21-,29?
SMILES Code
O=C(C1=CC=C(N(CC2=CC(OC)=C(C(NO)=O)C=C2)C=C3)C3=C1)NCC45C[C@@H]6C[C@@H](C[C@@H](C6)C5)C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 487.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bai P, Liu Y, Yang L, Ding W, Mondal P, Sang N, Liu G, Lu X, Ho TT, Zhou Y, Wu R, Birar VC, Wilks MQ, Tanzi RE, Lin H, Zhang C, Li W, Shen S, Wang C. Development and Pharmacochemical Characterization Discover a Novel Brain- Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice. J Med Chem. 2023 Nov 16. doi: 10.1021/acs.jmedchem.3c01491. Epub ahead of print. PMID: 37972387. 2: Tejel C, Sommovigo M, Ciriano MA, López JA, Lahoz FJ, Oro LA. Rhodium-Rhodium Bonds in Edge-Sharing Coplanar Dinuclear Complexes Generous financial support from DGES (Projects PB98-641, PB95-318, and PB94-1186) and a fellowship (to M.S.) are gratefully acknowledged. Angew Chem Int Ed Engl. 2000 Jul 3;39(13):2336-2339. PMID: 10941083. 3: Argilés A, García-García M, Derancourt J, Mourad G, Demaille JG. Beta 2 microglobulin isoforms in healthy individuals and in amyloid deposits. Kidney Int. 1995 Nov;48(5):1397-405. doi: 10.1038/ki.1995.428. PMID: 8544395. 4: Allen RJ, Scott GK. Comparison of the effects of different lipopolysaccharides on the serum bactericidal reactions of two strains of Escherichia coli. Infect Immun. 1981 Feb;31(2):831-2. doi: 10.1128/iai.31.2.831-832.1981. PMID: 7012024; PMCID: PMC351386.