PHA-680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. PHA-680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic. PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.
MedKoo Cat#: 406160
Name: PHA-680632
CAS#: 398493-79-3
Chemical Formula: C28H35N7O2
Exact Mass: 501.2852
Molecular Weight: 501.64
Elemental Analysis: C, 67.04; H, 7.03; N, 19.55; O, 6.38
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 59.80 | |
| DMSO | 53.3 | 106.32 | |
| DMSO:PBS (pH 7.2) (1:2) | 0.3 | 65.78 |
The following data is based on the product molecular weight 501.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
