RO-5508887 HCl | CAS#1310349-35-9 | BACE inhibitor

MedKoo Cat#: 125452 | Name: RO-5508887 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RO5508887, also known as RG-7129, is a potent BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM).

Chemical Structure

RO-5508887 HCl

CAS#1310349-35-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 125452

Name: RO-5508887 HCl

CAS#: 1310349-35-9 (HCl)

Chemical Formula: C18H15ClF3N5O2

Exact Mass: 425.0900

Molecular Weight: 425.80

Elemental Analysis: C, 50.77; H, 3.55; Cl, 8.33; F, 13.39; N, 16.45; O, 7.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1310347-50-2 (free base) 1310349-35-9 (HCl)

Synonym

8PU77BD4DA; RO-5508887 hydrochloride; UNII-8PU77BD4DA; 310349-35-9

IUPAC/Chemical Name

(R)-N-(3-(2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide hydrochloride

InChi Key

CNXVOHMMAKBONG-UNTBIKODSA-N

InChi Code

InChI=1S/C18H14F3N5O2.ClH/c1-17(18(20,21)9-28-16(23)26-17)12-6-11(3-4-13(12)19)25-15(27)14-5-2-10(7-22)8-24-14;/h2-6,8H,9H2,1H3,(H2,23,26)(H,25,27);1H/t17-;/m1./s1

SMILES Code

Cl.C[C@@]1(N=C(N)OCC1(F)F)C2=CC(NC(=O)C3=NC=C(C=C3)C#N)=CC=C2F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 425.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D, Tanghe A, Bohrmann B. Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice. J Neurosci. 2014 Aug 27;34(35):11621-30. doi: 10.1523/JNEUROSCI.1405-14.2014. PubMed PMID: 25164658; PubMed Central PMCID: PMC4145168.