Ralinepag sodium monohydrate | CAS#1187857-75-5 | PGI2 agonist

MedKoo Cat#: 125442 | Name: Ralinepag sodium monohydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ralinepag (APD-811) is an orally available agonist of the prostacyclin (IP) receptor intended for the treatment of vasospastic diseases such as Pulmonary Arterial Hypertension. Ralinepag has the potential to mimic prostacyclin -- the major product of cyclooxygenase -- in macrovascular endothelium This elicits a potent vasodilation response and inhibition of platelet aggregation when binding to this receptor.

Chemical Structure

Ralinepag sodium monohydrate

CAS#1187857-75-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 125442

Name: Ralinepag sodium monohydrate

CAS#: 1187857-75-5 (sodium)

Chemical Formula: C23H27ClNNaO6

Exact Mass: 471.1400

Molecular Weight: 471.91

Elemental Analysis: C, 58.54; H, 5.77; Cl, 7.51; N, 2.97; Na, 4.87; O, 20.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1187856-49-0 (free base) 1187857-75-5 (sodium)

Synonym

Ralinepag sodium monohydrate; UNII-AM550C29LE; AM550C29LE; 1187857-75-5

IUPAC/Chemical Name

sodium 2-(((1r,4r)-4-((((4-chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate hydrate

InChi Key

QDYNDSKQYZTUPW-PMXFUEHMSA-M

InChi Code

InChI=1S/C23H26ClNO5.Na.H2O/c24-19-10-12-21(13-11-19)25(20-4-2-1-3-5-20)23(28)30-15-18-8-6-17(7-9-18)14-29-16-22(26)27;;/h1-5,10-13,17-18H,6-9,14-16H2,(H,26,27);;1H2/q;+1;/p-1/t17-,18-;;

SMILES Code

O.[Na+].[O-]C(=O)COC[C@H]1CC[C@H](COC(=O)N(C2=CC=CC=C2)C3=CC=C(Cl)C=C3)CC1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 471.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Tran, T.-A., Kramer, B., Shin, Y.-J., et al. Discovery of 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralingepag): An orally active prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. J. Med. Chem. 60(3), 913-927 (2017).