COH1 | ribonucleotide reductase inhibitor | RR | CAS#20217-22-5

MedKoo Cat#: 125386 | Name: COH1 inhibitor

Description:

WARNING: This product is for research use only, not for human or veterinary use.

COH1 is a ribonucleotide reductase (RR) inhibitor.

Chemical Structure

COH1 inhibitor

CAS#20217-22-5

Theoretical Analysis

MedKoo Cat#: 125386

Name: COH1 inhibitor

CAS#: 20217-22-5

Chemical Formula: C11H10N2O3S

Exact Mass: 250.0412

Molecular Weight: 250.27

Elemental Analysis: C, 52.79; H, 4.03; N, 11.19; O, 19.18; S, 12.81

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,650.00	2 Weeks
2g	USD 5,650.00	2 Weeks

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Related CAS #

No Data

Synonym

COH1 inhibitor; COH-1 inhibitor; COH 1 inhibitor; COH-1; COH1;

IUPAC/Chemical Name

N-(4-(3,4-dihydroxyphenyl)thiazol-2-yl)acetamide

InChi Key

URUUPFDMCFXHGD-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H10N2O3S/c1-6(14)12-11-13-8(5-17-11)7-2-3-9(15)10(16)4-7/h2-5,15-16H,1H3,(H,12,13,14)

SMILES Code

O=C(C)NC1=NC(C2=CC(O)=C(O)C=C2)=CS1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 250.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ohtsuka H, Kawai S, Otsubo Y, Shimasaki T, Yamashita A, Aiba H. Metarhizium robertsii COH1 functionally complements Schizosaccharomyces pombe Ecl family proteins. J Gen Appl Microbiol. 2023 Oct 6. doi: 10.2323/jgam.2023.09.001. Epub ahead of print. PMID: 37813640. 2: Seifert W, Kühnisch J, Maritzen T, Lommatzsch S, Hennies HC, Bachmann S, Horn D, Haucke V. Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. J Biol Chem. 2015 Feb 6;290(6):3349-58. doi: 10.1074/jbc.M114.608174. Epub 2014 Dec 9. PMID: 25492866; PMCID: PMC4319006. 3: Seifert W, Kühnisch J, Maritzen T, Horn D, Haucke V, Hennies HC. Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity. J Biol Chem. 2011 Oct 28;286(43):37665-75. doi: 10.1074/jbc.M111.267971. Epub 2011 Aug 24. PMID: 21865173; PMCID: PMC3199510. 4: Athanasakis E, Fabretto A, Faletra F, Mocenigo M, Morgan A, Gasparini P. Two Novel COH1 Mutations in an Italian Patient with Cohen Syndrome. Mol Syndromol. 2012 Jun;3(1):30-33. doi: 10.1159/000338816. Epub 2012 May 16. PMID: 22855652; PMCID: PMC3398820. 5: Kondo I, Shimizu A, Asakawa S, Miyamoto K, Yamagata H, Tabara Y, Shimizu N. COH1 analysis and linkage study in two Japanese families with Cohen syndrome. Clin Genet. 2005 Mar;67(3):270-2. doi: 10.1111/j.1399-0004.2005.00396.x. PMID: 15691367. 6: Parri V, Katzaki E, Uliana V, Scionti F, Tita R, Artuso R, Longo I, Boschloo R, Vijzelaar R, Selicorni A, Brancati F, Dallapiccola B, Zelante L, Hamel CP, Sarda P, Lalani SR, Grasso R, Buoni S, Hayek J, Servais L, de Vries BB, Georgoudi N, Nakou S, Petersen MB, Mari F, Renieri A, Ariani F. High frequency of COH1 intragenic deletions and duplications detected by MLPA in patients with Cohen syndrome. Eur J Hum Genet. 2010 Oct;18(10):1133-40. doi: 10.1038/ejhg.2010.59. Epub 2010 May 12. PMID: 20461111; PMCID: PMC2987453. 7: Seifert W, Holder-Espinasse M, Spranger S, Hoeltzenbein M, Rossier E, Dollfus H, Lacombe D, Verloes A, Chrzanowska KH, Maegawa GH, Chitayat D, Kotzot D, Huhle D, Meinecke P, Albrecht B, Mathijssen I, Leheup B, Raile K, Hennies HC, Horn D. Mutational spectrum of COH1 and clinical heterogeneity in Cohen syndrome. J Med Genet. 2006 May;43(5):e22. doi: 10.1136/jmg.2005.039867. PMID: 16648375; PMCID: PMC2564527.