Colchinoic acid | CAS# 6714-14-3 | Biochemical

MedKoo Cat#: 573732 | Name: Colchinoic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Colchinoic acid is a biochemical that has been shown to bind to tubulin.

Chemical Structure

Colchinoic acid

CAS#6714-14-3

Theoretical Analysis

MedKoo Cat#: 573732

Name: Colchinoic acid

CAS#: 6714-14-3

Chemical Formula: C21H23NO6

Exact Mass: 385.1525

Molecular Weight: 385.42

Elemental Analysis: C, 65.44; H, 6.02; N, 3.63; O, 24.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Allocolchicein, Allocolchiceine, allocolchicine, Colchicic acid (8CI), Colchinoic acid, Colchicinoic acid

IUPAC/Chemical Name

5H-Dibenzo(a,c)cycloheptene-3-carboxylic acid, 5-(acetylamino)-6,7-dihydro-9,10,11-trimethoxy-, (S)- (9CI)

InChi Key

ZAIRUODZMPTJLF-UHFFFAOYSA-N

InChi Code

1S/C21H23NO6/c1-11(23)22-16-8-6-12-10-17(26-2)19(27-3)20(28-4)18(12)14-7-5-13(21(24)25)9-15(14)16/h5,7,9-10,16H,6,8H2,1-4H3,(H,22,23)(H,24,25)

SMILES Code

c12c3c(c(OC)c(cc3CC[C@@H](c1cc(cc2)C(=O)O)NC(=O)C)OC)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 385.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Djurdjevic S, Yang F, Green JR. Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. Synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (-)-allocolchicine. J Org Chem. 2010 Dec 3;75(23):8241-51. doi: 10.1021/jo101953n. Epub 2010 Nov 8. PubMed PMID: 21058661. 2: Hastie SB. Spectroscopic and kinetic features of allocolchicine binding to tubulin. Biochemistry. 1989 Sep 19;28(19):7753-60. PubMed PMID: 2611212. 3: Deinum J, Lincoln P. Binding to tubulin of an allocolchicine spin probe: interaction with the essential SH groups and other active sites. Biochim Biophys Acta. 1986 Mar 28;870(2):226-33. PubMed PMID: 3006777.