Colchicine Methanethiosulfonate | CAS# 1217821-52-7 | antimitotic

MedKoo Cat#: 574639 | Name: Colchicine Methanethiosulfonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Colchicine Methanethiosulfonate is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. It stimulates the intrinsic GTPase activity of tubulin and induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Chemical Structure

Colchicine Methanethiosulfonate

CAS#1217821-52-7

Theoretical Analysis

MedKoo Cat#: 574639

Name: Colchicine Methanethiosulfonate

CAS#: 1217821-52-7

Chemical Formula: C24H29NO8S2

Exact Mass: 523.1335

Molecular Weight: 523.61

Elemental Analysis: C, 55.05; H, 5.58; N, 2.68; O, 24.44; S, 12.25

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Synonym

Colchicine Methanethiosulfonate

IUPAC/Chemical Name

(S)-S-(3-oxo-3-((1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)amino)propyl) methanesulfonothioate

InChi Key

KZMCZFBQMMHSRF-KRWDZBQOSA-N

InChi Code

InChI=1S/C24H29NO8S2/c1-30-19-9-7-15-16(13-18(19)26)17(25-21(27)10-11-34-35(5,28)29)8-6-14-12-20(31-2)23(32-3)24(33-4)22(14)15/h7,9,12-13,17H,6,8,10-11H2,1-5H3,(H,25,27)/t17-/m0/s1

SMILES Code

O=C(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)CCSS(C)(=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 523.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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