Revatropate hydrobromide | muscarinic antagonist

MedKoo Cat#: 125204 | Name: Revatropate hydrobromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Revatropate is a selective muscarinic antagonist. It is an antimuscarinic drug.

Chemical Structure

Revatropate hydrobromide

CAS#262586-79-8 (HBr)

Theoretical Analysis

MedKoo Cat#: 125204

Name: Revatropate hydrobromide

CAS#: 262586-79-8 (HBr)

Chemical Formula: C19H28BrNO4S

Exact Mass: 445.0900

Molecular Weight: 446.40

Elemental Analysis: C, 51.12; H, 6.32; Br, 17.90; N, 3.14; O, 14.34; S, 7.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

586346-96-5 (HCl),149926-91-0 (free base) 262586-79-8 (HBr)

Synonym

Revatropate hydrobromide; UNII-5M406XG20G; 5M406XG20G; UK-112,166-04; 262586-79-8

IUPAC/Chemical Name

(R)-quinuclidin-3-yl (2S)-2-(hydroxymethyl)-4-(methylsulfinyl)-2-phenylbutanoate hydrobromide

InChi Key

WUBKMAXEHQTPBW-XPTPVYCOSA-N

InChi Code

InChI=1S/C19H27NO4S.BrH/c1-25(23)12-9-19(14-21,16-5-3-2-4-6-16)18(22)24-17-13-20-10-7-15(17)8-11-20;/h2-6,15,17,21H,7-14H2,1H3;1H/t17-,19+,25+;/m0./s1

SMILES Code

Br.C[S@@+]([O-])CC[C@](CO)(C(=O)O[C@H]1CN2CCC1CC2)C3=CC=CC=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: McGorum BC, Nicholas DR, Foster AP, Shaw DJ, Pirie RS. Bronchodilator activity of the selective muscarinic antagonist revatropate in horses with heaves. Vet J. 2013 Jan;195(1):80-5. doi: 10.1016/j.tvjl.2012.06.013. Epub 2012 Jul 31. PMID: 22850354. 2: Ticehurst MD, Basford PA, Dallman CI, Lukas TM, Marshall PV, Nichols G, Smith D. Characterisation of the influence of micronisation on the crystallinity and physical stability of revatropate hydrobromide. Int J Pharm. 2000 Jan 5;193(2):247-59. doi: 10.1016/s0378-5173(99)00347-6. PMID: 10606789. 3: Alabaster VA. Discovery & development of selective M3 antagonists for clinical use. Life Sci. 1997;60(13-14):1053-60. doi: 10.1016/s0024-3205(97)00047-7. PMID: 9121347. 4: Gaykar SK, Shinde RB, Bhalgat CM, Harlikar J, Gangrade M, Pullela SV. Development and Validation of Chiral HPLC Method for Quantification of 3-(S)-Quinuclidinol in Pharmaceutically Important Precursor, 3-(R)-Quinuclidinol, by Precolumn Derivatization. J Chromatogr Sci. 2016 Nov;54(10):1800-1805. doi: 10.1093/chromsci/bmw139. Epub 2016 Sep 27. PMID: 27681774.