PSB-KK1415 | GPR18

MedKoo Cat#: 127237 | Name: PSB-KK1415

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-KK1415 is a Potent, Selective Agonist for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18. PSB-KK1415 showed EC50 19.1 nM.

Chemical Structure

PSB-KK1415

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127237

Name: PSB-KK1415

CAS#: N/A

Chemical Formula: C24H23ClN6O2

Exact Mass: 462.1571

Molecular Weight: 462.94

Elemental Analysis: C, 62.27; H, 5.01; Cl, 7.66; N, 18.15; O, 6.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PSB-KK1415; PSBKK1415; PSB-KK-1415

IUPAC/Chemical Name

8-((2-(1H-indol-3-yl)ethyl)amino)-7-(4-chlorobenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

InChi Key

FHFDQEPXKZVEOI-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H23ClN6O2/c1-29-21-20(22(32)30(2)24(29)33)31(14-15-7-9-17(25)10-8-15)23(28-21)26-12-11-16-13-27-19-6-4-3-5-18(16)19/h3-10,13,27H,11-12,14H2,1-2H3,(H,26,28)

SMILES Code

O=C(N1C)N(C)C2=C(N(CC3=CC=C(Cl)C=C3)C(NCCC4=CNC5=C4C=CC=C5)=N2)C1=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kotańska M, Mika K, Szafarz M, Kubacka M, Müller CE, Sapa J, Kieć-Kononowicz K. Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating. Pharmaceuticals (Basel). 2021 Mar 16;14(3):270. doi: 10.3390/ph14030270. PMID: 33809564; PMCID: PMC8002110. 2: Mahardhika AB, Załuski M, Schoeder CT, Boshta NM, Schabikowski J, Perri F, Łażewska D, Neumann A, Kremers S, Oneto A, Ressemann A, Latacz G, Namasivayam V, Kieć-Kononowicz K, Müller CE. Potent, Selective Agonists for the Cannabinoid- like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423. Epub ahead of print. PMID: 38885438.