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MedKoo Cat#: 414259 | Name: KNI 174

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KNI 174 is a new type of anti‐AIDS drug used as an HIV‐1 protease inhibitor

Chemical Structure

KNI 174
KNI 174
CAS#141804-42-4

Theoretical Analysis

MedKoo Cat#: 414259

Name: KNI 174

CAS#: 141804-42-4

Chemical Formula: C36H45N5O7S

Exact Mass: 691.3040

Molecular Weight: 691.84

Elemental Analysis: C, 62.50; H, 6.56; N, 10.12; O, 16.19; S, 4.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KNI174; KNI-174; KNI 174
IUPAC/Chemical Name
(2S)-N1-((2S)-4-((R)-4-(tert-butylcarbamoyl)-5,5-dimethylthiazolidin-3-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(2-(naphthalen-1-yloxy)acetamido)succinamide
InChi Key
UFSMRNQSQSGJII-RDMYVLJUSA-N
InChi Code
InChI=1S/C36H45N5O7S/c1-35(2,3)40-33(46)31-36(4,5)49-21-41(31)34(47)30(44)25(18-22-12-7-6-8-13-22)39-32(45)26(19-28(37)42)38-29(43)20-48-27-17-11-15-23-14-9-10-16-24(23)27/h6-17,25-26,30-31,44H,18-21H2,1-5H3,(H2,37,42)(H,38,43)(H,39,45)(H,40,46)/t25-,26-,30?,31+/m0/s1
SMILES Code
CC(C)(NC([C@H]1N(C(C([C@@H](NC([C@@H](NC(COc(ccc2)c3c2cccc3)=O)CC(N)=O)=O)Cc4ccccc4)O)=O)CSC1(C)C)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 691.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kiriyama A, Mimoto T, Kiso Y, Takada K. Pharmacokinetic study of a tripeptide HIV-1 protease inhibitor, KNI-174, in rats after intravenous and intraduodenal administrations. Biopharm Drug Dispos. 1993 Apr;14(3):199-207. doi: 10.1002/bdd.2510140303. PMID: 8490108. 2: Kiriyama A, Mimoto T, Kisanuki S, Kiso Y, Takada K. Comparison of a new orally potent tripeptide HIV-1 protease inhibitor (anti-AIDS drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations. Biopharm Drug Dispos. 1993 Nov;14(8):697-707. doi: 10.1002/bdd.2510140806. PMID: 8305629.