KM04794 | CAS# 882287-24-3 | Modulator

MedKoo Cat#: 208372 | Name: KM04794

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KM04794 is a chaperone-like small molecule that alleviates ER stress. KM04794 prevented protein aggregation and cell death caused by ER stressors and a mutant insulin protein.

Chemical Structure

KM04794

CAS# 882287-24-3

Theoretical Analysis

MedKoo Cat#: 208372

Name: KM04794

CAS#: 882287-24-3

Chemical Formula: C23H18ClF3N2O3S

Exact Mass: 494.0679

Molecular Weight: 494.91

Elemental Analysis: C, 55.82; H, 3.67; Cl, 7.16; F, 11.52; N, 5.66; O, 9.70; S, 6.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KM-04794, K-M04794

IUPAC/Chemical Name

N'-(2-(2-((4-Chlorobenzyl)thio)phenoxy)acetyl)-3-(trifluoromethyl)benzohydrazide

InChi Key

CTHFEQURMFRYPT-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H18ClF3N2O3S/c24-18-10-8-15(9-11-18)14-33-20-7-2-1-6-19(20)32-13-21(30)28-29-22(31)16-4-3-5-17(12-16)23(25,26)27/h1-12H,13-14H2,(H,28,30)(H,29,31)

SMILES Code

FC(F)(F)C1=CC=CC(C(NNC(COC2=C(SCC3=CC=C(Cl)C=C3)C=CC=C2)=O)=O)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 494.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Miyake M, Sobajima M, Kurahashi K, Shigenaga A, Denda M, Otaka A, Saio T, Sakane N, Kosako H, Oyadomari S. Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells. Cell Chem Biol. 2022 Jun 16;29(6):996-1009.e9. doi: 10.1016/j.chembiol.2022.01.002. Epub 2022 Feb 9. PMID: 35143772.