Synonym
GW273293; GW-273293; GW 273293; JZP-4; JZP 4; JZP4; Elpetrigine.
IUPAC/Chemical Name
3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine
InChi Key
NNXUYJFHOVCRSM-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H7Cl3N4/c11-4-1-5(8(13)6(12)2-4)9-10(15)17-7(14)3-16-9/h1-3H,(H4,14,15,17)
SMILES Code
NC1=NC(N)=CN=C1C2=CC(Cl)=CC(Cl)=C2Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
289.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin
Pharmacol. 2009 Mar;31(2):107-46. PubMed PMID: 19455266.
2: Foreman MM, Hanania T, Eller M. Anxiolytic effects of lamotrigine and JZP-4 in
the elevated plus maze and in the four plate conflict test. Eur J Pharmacol. 2009
Jan 14;602(2-3):316-20. doi: 10.1016/j.ejphar.2008.11.013. Epub 2008 Nov 17.
PubMed PMID: 19038245.
3: Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress
report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT
IX). Epilepsy Res. 2009 Jan;83(1):1-43. doi: 10.1016/j.eplepsyres.2008.09.005.
Epub 2008 Nov 12. PubMed PMID: 19008076.
4: Foreman MM, Hanania T, Stratton SC, Wilcox KS, White HS, Stables JP, Eller M.
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for
anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav.
2008 Jun;89(4):523-34. doi: 10.1016/j.pbb.2008.02.007. Epub 2008 Feb 11. PubMed
PMID: 18377968.
5: Landmark CJ, Johannessen SI. Modifications of antiepileptic drugs for improved
tolerability and efficacy. Perspect Medicin Chem. 2008 Feb 14;2:21-39. PubMed
PMID: 19787095; PubMed Central PMCID: PMC2746576.
6: Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Perucca E, Tomson T.
Progress report on new antiepileptic drugs: a summary of the Eigth Eilat
Conference (EILAT VIII). Epilepsy Res. 2007 Jan;73(1):1-52. Epub 2006 Dec 8.
PubMed PMID: 17158031.
