SKQ1, also known as Visomitin, plastoquinonyl decyltriphenyl phosphonium or PDTP, is a potent mitochondria-targeted antioxidant. SKQ1 is also an API for making eye drop drug called Visomitin. SKQ1 showed activities (1) to prevent amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices; (2) to reverse aging-related biomarkers in rats; (3) to slow down the development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats; (4) to increase the lifespan of male rodents under LP or SPF conditions. SKQ1 can penetrate cell membranes , and is proposed as an anti-aging treatment. Visomitin, which API is SKQ1, is currently under clinical trials for treating glaucoma in Russia. Note: For the convenience of use, SKQ1 is supplied as solution of 200mg / mL in ethanol-water (1:1, v/v).
MedKoo Cat#: 125153
Name: SKQ-1 chloride
CAS#: 1372443-45-2 (chloride)
Chemical Formula: C36H42ClO2P
Exact Mass: 537.2900
Molecular Weight: 573.15
Elemental Analysis: C, 75.44; H, 7.39; Cl, 6.19; O, 5.58; P, 5.40
The following data is based on the product molecular weight 573.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
