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MedKoo Cat#: 124969 | Name: Yohimbine C-11

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Yohimbine C-11 is a PET tracer.

Chemical Structure

Yohimbine C-11
Yohimbine C-11
CAS#947767-67-1

Theoretical Analysis

MedKoo Cat#: 124969

Name: Yohimbine C-11

CAS#: 947767-67-1

Chemical Formula: C2011CH26N2O3

Exact Mass: 353.2100

Molecular Weight: 353.45

Elemental Analysis: C, 71.08; H, 7.41; N, 7.93; O, 13.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
11c-Yohimbine; (11C)Yohimbine; Yohimbine C-11; 7G5I8N2S10; UNII-7G5I8N2S10
IUPAC/Chemical Name
methyl-11C (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
InChi Key
BLGXFZZNTVWLAY-OPQCJPJISA-N
InChi Code
InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1/i1-1
SMILES Code
[11CH3]OC([C@]1([H])[C@@]2([H])C[C@@]3([H])C4=C(C5=CC=CC=C5N4)CCN3C[C@]2([H])CC[C@]1([H])O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nahimi A, Jakobsen S, Munk OL, Vang K, Phan JA, Rodell A, Gjedde A. Mapping α2 adrenoceptors of the human brain with 11C-yohimbine. J Nucl Med. 2015 Mar;56(3):392-8. doi: 10.2967/jnumed.114.145565. Epub 2015 Jan 29. PMID: 25635132. 2: Jakobsen S, Pedersen K, Smith DF, Jensen SB, Munk OL, Cumming P. Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine. J Nucl Med. 2006 Dec;47(12):2008-15. PMID: 17138744. 3: Landau AM, Doudet DJ, Jakobsen S. Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain. Psychopharmacology (Berl). 2012 Jul;222(1):155-63. doi: 10.1007/s00213-011-2632-6. Epub 2012 Jan 7. PMID: 22227612. 4: Laurencin C, Lancelot S, Merida I, Costes N, Redouté J, Le Bars D, Boulinguez P, Ballanger B. Distribution of α2-Adrenergic Receptors in the Living Human Brain Using [11C]yohimbine PET. Biomolecules. 2023 May 15;13(5):843. doi: 10.3390/biom13050843. PMID: 37238713; PMCID: PMC10216046. 5: Landau AM, Jakobsen S, Thomsen MB, Alstrup AKO, Orlowski D, Jacobsen J, Wegener G, Mørk A, Sørensen JCH, Doudet DJ. Combined In Vivo Microdialysis and PET Studies to Validate [11C]Yohimbine Binding as a Marker of Noradrenaline Release. Biomolecules. 2023 Apr 14;13(4):674. doi: 10.3390/biom13040674. PMID: 37189421; PMCID: PMC10136072.