Handelin | CAS#62687-22-3

MedKoo Cat#: 341130 | Name: Handelin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Handelin is a biochemical.

Chemical Structure

Handelin

CAS#62687-22-3

Theoretical Analysis

MedKoo Cat#: 341130

Name: Handelin

CAS#: 62687-22-3

Chemical Formula: C32H40O8

Exact Mass: 552.2723

Molecular Weight: 552.66

Elemental Analysis: C, 69.55; H, 7.30; O, 23.16

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 450.00	2 Weeks

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Related CAS #

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Synonym

Handelin; Yejuhua lactone

IUPAC/Chemical Name

Spiro(azuleno(4,5-b)furan-3(2H),10'-(4H-6a,9)ethanoazuleno(4,5-b)furan)-2,2'(3'H)-dione, 4-(acetyloxy)-3a,3'a,4,5,5',6,6',6a,7,9',9a,9'a,9b,9'b-tetradecahydro-6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-, (3'aS-(3'aalpha,6'alpha,6'aa lpha,9'alpha,9'aalpha,9'bbeta,10'S*(3aS*,4R*,6S*,6aS*,9aS*,9bS*)))-

InChi Key

DSNIKOZTDZBWKD-XMNJDQQWSA-N

InChi Code

InChI=1S/C32H40O8/c1-15-7-8-19-22(15)24-20(13-21(30(19,6)37)38-17(3)33)32(27(35)40-24)14-31-12-11-28(32,4)25(31)23-18(9-10-29(31,5)36)16(2)26(34)39-23/h7,11-12,18-25,36-37H,2,8-10,13-14H2,1,3-6H3/t18?,19?,20?,21-,22?,23+,24+,25?,28?,29-,30+,31?,32?/m1/s1

SMILES Code

CC1=CCC2C1[C@@H]3C(C[C@H]([C@@]2(C)O)OC(=O)C)C4(CC56C=CC4(C5[C@@H]7C(CC[C@@]6(C)O)C(=C)C(=O)O7)C)C(=O)O3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 552.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang LC, Liao LX, Lv HN, Liu D, Dong W, Zhu J, Chen JF, Shi ML, Fu G, Song XM, Jiang Y, Zeng KW, Tu PF. Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition. EBioMedicine. 2017 Sep;23:160-172. doi: 10.1016/j.ebiom.2017.08.011. Epub 2017 Aug 9. PubMed PMID: 28807514; PubMed Central PMCID: PMC5605382. 2: Pyee Y, Chung HJ, Choi TJ, Park HJ, Hong JY, Kim JS, Kang SS, Lee SK. Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production. J Nat Prod. 2014 Apr 25;77(4):917-24. doi: 10.1021/np4009877. Epub 2014 Apr 1. PubMed PMID: 24689881. 3: Frudakis TN, Thomas MJ, Ginjupalli SN, Handelin B, Gabriel R, Gomez HJ. CYP2D6*4 polymorphism is associated with statin-induced muscle effects. Pharmacogenet Genomics. 2007 Sep;17(9):695-707. PubMed PMID: 17700359. 4: Timmreck LS, Gray MR, Handelin B, Allito B, Rohlfs E, Davis AJ, Gidwani G, Reindollar RH. Analysis of cystic fibrosis transmembrane conductance regulator gene mutations in patients with congenital absence of the uterus and vagina. Am J Med Genet A. 2003 Jul 1;120A(1):72-6. PubMed PMID: 12794695. 5: Zielenski J, Patrizio P, Corey M, Handelin B, Markiewicz D, Asch R, Tsui LC. CFTR gene variant for patients with congenital absence of vas deferens. Am J Hum Genet. 1995 Oct;57(4):958-60. PubMed PMID: 7573058; PubMed Central PMCID: PMC1801510. 6: Patrizio P, Asch RH, Handelin B, Silber SJ. Aetiology of congenital absence of vas deferens: genetic study of three generations. Hum Reprod. 1993 Feb;8(2):215-20. PubMed PMID: 8473422. 7: Shuber AP, Skoletsky J, Stern R, Handelin BL. Efficient 12-mutation testing in the CFTR gene: a general model for complex mutation analysis. Hum Mol Genet. 1993 Feb;2(2):153-8. PubMed PMID: 7684636. 8: Handelin B, Wachbroit R, Billings P, Scheck B, Reilly P, Milunsky A. Genetic testing and individual rights. Suffolk Univ Law Rev. 1993 Winter;27(4):1477-97. PubMed PMID: 11657046. 9: Albin RL, Reiner A, Anderson KD, Dure LS 4th, Handelin B, Balfour R, Whetsell WO Jr, Penney JB, Young AB. Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease. Ann Neurol. 1992 Apr;31(4):425-30. PubMed PMID: 1375014. 10: Doucette-Stamm LA, Riba L, Handelin B, Difilippantonio M, Ward DC, Wasmuth JJ, Gusella JF, Housman DE. Generation and characterization of irradiation hybrids of human chromosome 4. Somat Cell Mol Genet. 1991 Sep;17(5):471-80. PubMed PMID: 1837181. 11: Albin RL, Young AB, Penney JB, Handelin B, Balfour R, Anderson KD, Markel DS, Tourtellotte WW, Reiner A. Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease. N Engl J Med. 1990 May 3;322(18):1293-8. PubMed PMID: 1691447. 12: Warburton D, Gersen S, Yu MT, Jackson C, Handelin B, Housman D. Monochromosomal rodent-human hybrids from microcell fusion of human lymphoblastoid cells containing an inserted dominant selectable marker. Genomics. 1990 Feb;6(2):358-66. PubMed PMID: 2307476. 13: Lugo TG, Handelin B, Killary AM, Housman DE, Fournier RE. Isolation of microcell hybrid clones containing retroviral vector insertions into specific human chromosomes. Mol Cell Biol. 1987 Aug;7(8):2814-20. PubMed PMID: 2823107; PubMed Central PMCID: PMC367898. 14: Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science. 1987 Jul 17;237(4812):268-75. PubMed PMID: 3037703. 15: Gerhard DS, Jones C, Morse HG, Handelin B, Weeks V, Housman D. Analysis of human chromosome 11 by somatic cell genetics: reexamination of derivatives of human-hamster cell line J1. Somat Cell Mol Genet. 1987 Jul;13(4):293-304. PubMed PMID: 3331828. 16: Chen ZN, Xu PJ. [Structural determination of yejuhua lactone, isolated from Chrysanthemum indicum L]. Yao Xue Xue Bao. 1987 Jan;22(1):67-9. Chinese. PubMed PMID: 3604697. 17: Handelin BL, Kabat D. Cell surface receptors for murine leukemia viruses: two assays and their implications. Virology. 1985 Jan 15;140(1):183-7. PubMed PMID: 3966298.