MedKoo Cat#: 573983 | Name: (+)-Pinoresinol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(+)-Pinoresinol is a lignan that diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties. It is an inhibitor of α-glucosidase and maltase. (+)-Pinoresinol scavenges ABTS but not 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in cell-free assays. It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37 cells. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells and inhibits LPS-induced nitric oxide production in RAW 264.7 cells.

Chemical Structure

(+)-Pinoresinol
(+)-Pinoresinol
CAS#487-36-5

Theoretical Analysis

MedKoo Cat#: 573983

Name: (+)-Pinoresinol

CAS#: 487-36-5

Chemical Formula: C20H22O6

Exact Mass: 358.1416

Molecular Weight: 358.39

Elemental Analysis: C, 67.03; H, 6.19; O, 26.78

Price and Availability

Size Price Availability Quantity
5mg USD 375.00
10mg USD 540.00
25mg USD 900.00
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Related CAS #
No Data
Synonym
(+)-Pinoresinol, NSC 35444
IUPAC/Chemical Name
4,4'-((1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol)
InChi Key
HGXBRUKMWQGOIE-AFHBHXEDSA-N
InChi Code
InChI=1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3/t13-,14-,19+,20+/m0/s1
SMILES Code
OC(C=C1)=C(OC)C=C1[C@@H]2[C@@]3([H])CO[C@H](C4=CC(OC)=C(O)C=C4)[C@@]3([H])CO2
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. López-Biedma, A., Sánchez-Quesada, C., Delgado-Rodríguez, M., et al. The biological activities of natural lignans from olives and virgin olive oils: A review. J. Funct. Foods 26, 36-47 (2016). 2. Li, D.-Q., Wang, D., Zhou, L., et al. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense. J. Asian Nat. Prod. Res. 19(5), 519-527 (2017). 3. Wikul, A., Damsud, T., Kataoka, K., et al. (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorg. Med. Chem. Lett. 22(16), 5215-5217 (2012). 4. In, S.-J., Seo, K.-H., Song, N.-Y., et al. Lignans and neolignans from the stems of Vibrunum erosum and their neuroprotective and anti-inflammatory activity. Arch. Pharm. Res. 38(1), 26-34 (2015).