HTS07545 is a potent first-in-class inhibitor of sulfide:quinone oxidoreductase (SQOR) with an IC₅₀ of 29 nM. It selectively binds to the coenzyme Q-binding pocket of SQOR, exhibiting low cytotoxicity. It mitigates cardiac remodeling, fibrosis, and heart failure progression in animal models, offering a potential therapeutic approach for heart failure with reduced ejection fraction (HFrEF).
MedKoo Cat#: 124856
Name: HTS07545
CAS#: 118666-03-8
Chemical Formula: C22H18N2O3
Exact Mass: 358.1317
Molecular Weight: 358.36
Elemental Analysis: C, 73.73; H, 5.06; N, 7.82; O, 13.39
The following data is based on the product molecular weight 358.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
