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MedKoo Cat#: 529805 | Name: HT-2157
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

HT-2157， also called SNAP-37889， is a Galanin-3 (GAL3) antagonist potentially for the treatment of major depressive disorder.

Chemical Structure

HT-2157
HT-2157
CAS#303149-14-6

Theoretical Analysis

MedKoo Cat#: 529805

Name: HT-2157

CAS#: 303149-14-6

Chemical Formula: C21H13F3N2O

Exact Mass: 366.0980

Molecular Weight: 366.34

Elemental Analysis: C, 68.85; H, 3.58; F, 15.56; N, 7.65; O, 4.37

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 680.00 2 Weeks
50mg USD 1,050.00 2 Weeks
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Related CAS #
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Synonym
HT-2157; SNAP-37889; HT2157; SNAP37889; HT 2157; SNAP 37889
IUPAC/Chemical Name
(Z)-1-phenyl-3-((3-(trifluoromethyl)phenyl)imino)indolin-2-one
InChi Key
TXCGMRVPXUBHAL-PLRJNAJWSA-N
InChi Code
InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19-
SMILES Code
O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)/C1=N/C4=CC=CC(C(F)(F)F)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
In vitro activity:
TBD
In vivo activity:
Unexpectedly, coinjection of M871 with spexin could not block the inhibitory effect of spexin on food intake (p=0.430, compared with the spexin group), suggesting that GALR2 was not involved in the anorectic effect of spexin. Figure 2(b) demonstrates that SNAP37889 also did not influence cumulative food intake at 6 h (p=0.999, compared with the control). However, it significantly antagonized the inhibition of food intake induced by spexin (p < 0.05, compared with the spexin group), indicating that the anorectic effect of spexin was mediated by GALR3. Reference: Int J Endocrinol. 2020 Aug 5;2020:4913785. https://pubmed.ncbi.nlm.nih.gov/32831833/
Solvent mg/mL mM comments
Solubility
DMF 30.0 81.89
DMSO 44.0 120.11
Ethanol 7.0 19.11
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 366.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Lv S, Zhou Y, Feng Y, Zhang X, Wang X, Yang Y, Wang X. Peripheral Spexin Inhibited Food Intake in Mice. Int J Endocrinol. 2020 Aug 5;2020:4913785. doi: 10.1155/2020/4913785. PMID: 32831833; PMCID: PMC7426757. 2. Lin CY, Zhang M, Huang T, Yang LL, Fu HB, Zhao L, Zhong LL, Mu HX, Shi XK, Leung CF, Fan BM, Jiang M, Lu AP, Zhu LX, Bian ZX. Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice. Sci Rep. 2015 Jul 10;5:12095. doi: 10.1038/srep12095. PMID: 26160593; PMCID: PMC4498193.
In vitro protocol:
TBD
In vivo protocol:
1. Lv S, Zhou Y, Feng Y, Zhang X, Wang X, Yang Y, Wang X. Peripheral Spexin Inhibited Food Intake in Mice. Int J Endocrinol. 2020 Aug 5;2020:4913785. doi: 10.1155/2020/4913785. PMID: 32831833; PMCID: PMC7426757. 2. Lin CY, Zhang M, Huang T, Yang LL, Fu HB, Zhao L, Zhong LL, Mu HX, Shi XK, Leung CF, Fan BM, Jiang M, Lu AP, Zhu LX, Bian ZX. Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice. Sci Rep. 2015 Jul 10;5:12095. doi: 10.1038/srep12095. PMID: 26160593; PMCID: PMC4498193.
1: Koller A, Rid R, Beyreis M, Bianchini R, Holub BS, Lang A, Locker F, Brodowicz B, Velickovic O, Jakab M, Kerschbaum H, Önder K, Kofler B. In vitro toxicity of the galanin receptor 3 antagonist SNAP 37889. Neuropeptides. 2016 Apr;56:83-8. doi: 10.1016/j.npep.2015.12.003. PubMed PMID: 26725588. 2: Ash BL, Quach T, Williams SJ, Lawrence AJ, Djouma E. Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats. J Pharmacol Sci. 2014;125(2):211-6. PubMed PMID: 24881957. 3: Ash BL, Zanatta SD, Williams SJ, Lawrence AJ, Djouma E. The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. Regul Pept. 2011 Jan 17;166(1-3):59-67. doi: 10.1016/j.regpep.2010.08.009. PubMed PMID: 20736033. 4: Scheller KJ, Williams SJ, Lawrence AJ, Jarrott B, Djouma E. An improved method to prepare an injectable microemulsion of the galanin-receptor 3 selective antagonist, SNAP 37889, using Kolliphor(®) HS 15. MethodsX. 2014 Sep 26;1:212-6. doi: 10.1016/j.mex.2014.09.003. PubMed PMID: 26150955; PubMed Central PMCID: PMC4472996. 5: Kothandan G, Gadhe CG, Cho SJ. Theoretical characterization of galanin receptor type 3 (Gal3 ) and its interaction with agonist (GALANIN) and antagonists (SNAP 37889 and SNAP 398299): an in silico analysis. Chem Biol Drug Des. 2013 Jun;81(6):757-74. doi: 10.1111/cbdd.12128. PubMed PMID: 23461969. 6: Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hökfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H, Walker MW, Craig DA, Gerald CP, Branchek TA. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14978. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5632. PubMed PMID: 16287967; PubMed Central PMCID: PMC1283534. 7: Barreto SG, Bazargan M, Zotti M, Hussey DJ, Sukocheva OA, Peiris H, Leong M, Keating DJ, Schloithe AC, Carati CJ, Smith C, Toouli J, Saccone GT. Galanin receptor 3--a potential target for acute pancreatitis therapy. Neurogastroenterol Motil. 2011 Mar;23(3):e141-51. doi: 10.1111/j.1365-2982.2010.01662.x. PubMed PMID: 21303427. 8: Bovell DL, Holub BS, Odusanwo O, Brodowicz B, Rauch I, Kofler B, Lang R. Galanin is a modulator of eccrine sweat gland secretion. Exp Dermatol. 2013 Feb;22(2):141-3. doi: 10.1111/exd.12067. PubMed PMID: 23278944. 9: Bajo M, Madamba SG, Lu X, Sharkey LM, Bartfai T, Siggins GR. Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. Addict Biol. 2012 Jul;17(4):694-705. doi: 10.1111/j.1369-1600.2011.00360.x. PubMed PMID: 21955024; PubMed Central PMCID: PMC3252398. 10: Schmidhuber SM, Rauch I, Kofler B, Brain SD. Evidence that the modulatory effect of galanin on inflammatory edema formation is mediated by the galanin receptor 3 in the murine microvasculature. J Mol Neurosci. 2009 Feb;37(2):177-81. doi: 10.1007/s12031-008-9135-x. PubMed PMID: 18679831. 11: Ogren SO, Kuteeva E, Hökfelt T, Kehr J. Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders. CNS Drugs. 2006;20(8):633-54. Review. PubMed PMID: 16863269. 12: Lin CY, Zhang M, Huang T, Yang LL, Fu HB, Zhao L, Zhong LL, Mu HX, Shi XK, Leung CF, Fan BM, Jiang M, Lu AP, Zhu LX, Bian ZX. Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice. Sci Rep. 2015 Jul 10;5:12095. doi: 10.1038/srep12095. PubMed PMID: 26160593; PubMed Central PMCID: PMC4498193. 13: Boudaka A, Wörl J, Shiina T, Shimizu Y, Takewaki T, Neuhuber WL. Galanin modulates vagally induced contractions in the mouse oesophagus. Neurogastroenterol Motil. 2009 Feb;21(2):180-8. doi: 10.1111/j.1365-2982.2008.01224.x. PubMed PMID: 19077146. 14: Page AJ, Slattery JA, Brierley SM, Jacoby AS, Blackshaw LA. Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity. J Physiol. 2007 Sep 1;583(Pt 2):675-84. PubMed PMID: 17627995; PubMed Central PMCID: PMC2277026.