| MedKoo

MedKoo Cat#: 124809 | Name: Sulcardine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulcardine is a multi-ion channel blocker potentially for the treatment of arrhythmia.

Chemical Structure

Sulcardine

CAS#343935-60-4 (free base)

Theoretical Analysis

MedKoo Cat#: 124809

Name: Sulcardine

CAS#: 343935-60-4 (free base)

Chemical Formula: C24H33N3O4S

Exact Mass: 459.2200

Molecular Weight: 459.61

Elemental Analysis: C, 62.72; H, 7.24; N, 9.14; O, 13.92; S, 6.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

343935-60-4 (free base) 343935-61-5 (sulfate) 934843-86-4 (sulfate trihydrate)

Synonym

Sulcardine; UNII-4Q5HLV8HG1; 4Q5HLV8HG1; 343935-60-4

IUPAC/Chemical Name

N-(4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)benzyl)-4-methoxybenzenesulfonamide

InChi Key

SYZGIWXQGIBJGN-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H33N3O4S/c1-31-22-6-8-23(9-7-22)32(29,30)25-16-19-14-20(17-26-10-2-3-11-26)24(28)21(15-19)18-27-12-4-5-13-27/h6-9,14-15,25,28H,2-5,10-13,16-18H2,1H3

SMILES Code

COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC(=C(C(=C2)CN3CCCC3)O)CN4CCCC4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 459.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang W, Qian HJ, Xin L, Zhang MQ, Lu DY, Jin JM, Liu GY, Jia JY, Zheng HC, Yu C, Wang YP, Zhu F, Liu Y. Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study. Eur J Drug Metab Pharmacokinet. 2016 Aug 22. [Epub ahead of print] PubMed PMID: 27550655. 2: Jia J, Liu G, Zhang M, Lu Y, Lu C, Liu Y, Zheng H, Wang W, Gui Y, Yu C, Li S, Wang Y. Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study. Biomed Chromatogr. 2016 Aug;30(8):1291-6. doi: 10.1002/bmc.3681. PubMed PMID: 26715470. 3: Chen Q, Qian HJ, Wang W, Zhang MQ, Lu DY, Lu C, Jin JM, Hu CY, Liu GY, Jia JY, Zheng HC, Li XN, Yu C, Wang YP, Liu Y. Pharmacokinetics, safety, and tolerability of sulcardine sulfate: an open-label, single-dose, randomized study in healthy Chinese subjects. Fundam Clin Pharmacol. 2017 Feb;31(1):120-125. doi: 10.1111/fcp.12242. PubMed PMID: 27599871. 4: Lu YL, Li SJ, Liu GY, Li XC, Yang D, Jia JY, Zhang MQ, Zheng HC, Yu C, Zhu F, Wang YP. Oral Bioavailability and Mass Balance Studies of a Novel Anti-arrhythmic Agent Sulcardine Sulfate in Sprague-Dawley Rats and Beagle Dogs. Eur J Drug Metab Pharmacokinet. 2016 Jul 11. [Epub ahead of print] PubMed PMID: 27402487. 5: Lee JY, Lucchesi BR. HBI-3000 prevents secondary sudden cardiac death. J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):453-9. doi: 10.1177/1074248413485433. PubMed PMID: 23615576. 6: Bai DL, Chen WZ, Bo YX, Dong YL, Kang AL, Sun WK, Wang W, Hu ZL, Wang YP. Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012 Sep;33(9):1176-86. doi: 10.1038/aps.2012.119. PubMed PMID: 22922342; PubMed Central PMCID: PMC4003109. 7: Guo D, Liu Q, Liu T, Elliott G, Gingras M, Kowey PR, Yan GX. Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85. doi: 10.1097/FJC.0b013e3181ffe8b3. PubMed PMID: 20980921.