Sulcardine sulfate trihydrate | CAS# 934843-86-4 | Biochemical

MedKoo Cat#: 576199 | Name: Sulcardine sulfate trihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulcardine sulfate trihydrate is a multi-ion channel blocker potentially for the treatment of arrhythmia.

Chemical Structure

Sulcardine sulfate trihydrate

CAS#934843-86-4 (sulfate trihydrate)

Theoretical Analysis

MedKoo Cat#: 576199

Name: Sulcardine sulfate trihydrate

CAS#: 934843-86-4 (sulfate trihydrate)

Chemical Formula: C24H42N4O10S2

Exact Mass: 610.2342

Molecular Weight: 610.74

Elemental Analysis: C, 47.20; H, 6.93; N, 9.17; O, 26.20; S, 10.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

343935-60-4 (free base) 343935-61-5 (sulfate) 934843-86-4 (sulfate trihydrate)

Synonym

HBI-3000 trihydrate; HBI 3000 trihydrate; HBI3000 trihydrate; Sulcardine sulfate trihydrate

IUPAC/Chemical Name

benzenesulfonamide, n-((4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl)methyl)-4-methoxy-, sulfame, hydrate (1:1:3)

InChi Key

XRPLNQWCUWWLGG-UHFFFAOYSA-N

InChi Code

1S/C24H33N3O4S.H2O4S.3H2O/c1-31-22-6-8-23(9-7-22)32(29,30)25-16-19-14-20(17-26-10-2-3-11-26)24(28)21(15-19)18-27-12-4-5-13-27;1-5(2,3)4;;;/h6-9,14-15,25,28H,2-5,10-13,16-18H2,1H3;(H2,1,2,3,4);3*1H2

SMILES Code

O.O.O.COc1ccc(cc1)S(=O)(=O)NCc2cc(CN3CCCC3)c(O)c(CN4CCCC4)c2.OS(=O)(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 610.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang W, Qian HJ, Xin L, Zhang MQ, Lu DY, Jin JM, Liu GY, Jia JY, Zheng HC, Yu C, Wang YP, Zhu F, Liu Y. Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study. Eur J Drug Metab Pharmacokinet. 2016 Aug 22. [Epub ahead of print] PubMed PMID: 27550655. 2: Jia J, Liu G, Zhang M, Lu Y, Lu C, Liu Y, Zheng H, Wang W, Gui Y, Yu C, Li S, Wang Y. Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study. Biomed Chromatogr. 2016 Aug;30(8):1291-6. doi: 10.1002/bmc.3681. PubMed PMID: 26715470. 3: Chen Q, Qian HJ, Wang W, Zhang MQ, Lu DY, Lu C, Jin JM, Hu CY, Liu GY, Jia JY, Zheng HC, Li XN, Yu C, Wang YP, Liu Y. Pharmacokinetics, safety, and tolerability of sulcardine sulfate: an open-label, single-dose, randomized study in healthy Chinese subjects. Fundam Clin Pharmacol. 2017 Feb;31(1):120-125. doi: 10.1111/fcp.12242. PubMed PMID: 27599871. 4: Lu YL, Li SJ, Liu GY, Li XC, Yang D, Jia JY, Zhang MQ, Zheng HC, Yu C, Zhu F, Wang YP. Oral Bioavailability and Mass Balance Studies of a Novel Anti-arrhythmic Agent Sulcardine Sulfate in Sprague-Dawley Rats and Beagle Dogs. Eur J Drug Metab Pharmacokinet. 2016 Jul 11. [Epub ahead of print] PubMed PMID: 27402487.