1400W | inhibitor of nitric oxide synthase | CAS#180001-34-7

MedKoo Cat#: 124794 | Name: 1400W

Description:

WARNING: This product is for research use only, not for human or veterinary use.

1400W is an inhibitor of nitric oxide synthase.

Chemical Structure

1400W

CAS#180001-34-7 (free base)

Theoretical Analysis

MedKoo Cat#: 124794

Name: 1400W

CAS#: 180001-34-7 (free base)

Chemical Formula: C10H15N3

Exact Mass: 177.1300

Molecular Weight: 177.25

Elemental Analysis: C, 67.76; H, 8.53; N, 23.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

180001-34-7 (free base) 214358-33-5 (HCl)

Synonym

1400W; 180001-34-7; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; n-[3-(aminomethyl)benzyl]acetamidine; W 1400

IUPAC/Chemical Name

(Z)-N'-(3-(aminomethyl)benzyl)acetimidamide

InChi Key

RODUKNYOEVZQPR-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)

SMILES Code

C/C(N)=N/CC1=CC=CC(CN)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 177.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pasten C, Lozano M, Méndez GP, Irarrázabal CE. 1400W Prevents Renal Injury in the Renal Cortex But Not in the Medulla in a Murine Model of Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2022 Oct 19;56(5):573-586. doi: 10.33594/000000577. PMID: 36259161. 2: Shi Q, Liu X, Wang N, Zheng X, Ran J, Liu Z, Fu J, Zheng J. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199. doi: 10.1016/j.bbr.2016.11.039. Epub 2016 Nov 22. PMID: 27888018. 3: Putra M, Vasanthi SS, Rao NS, Meyer C, Van Otterloo M, Thangi L, Thedens DR, Kannurpatti SS, Thippeswamy T. Inhibiting Inducible Nitric Oxide Synthase with 1400W Reduces Soman (GD)-Induced Ferroptosis in Long-Term Epilepsy-Associated Neuropathology: Structural and Functional Magnetic Resonance Imaging Correlations with Neurobehavior and Brain Pathology. J Pharmacol Exp Ther. 2024 Jan 17;388(2):724-738. doi: 10.1124/jpet.123.001929. PMID: 38129129; PMCID: PMC10801728. 4: Puttachary S, Sharma S, Verma S, Yang Y, Putra M, Thippeswamy A, Luo D, Thippeswamy T. 1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy. Neurobiol Dis. 2016 Sep;93:184-200. doi: 10.1016/j.nbd.2016.05.013. Epub 2016 May 18. PMID: 27208748. 5: Hosgood SA, Yates PJ, Nicholson ML. 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor. World J Transplant. 2014 Dec 24;4(4):299-305. doi: 10.5500/wjt.v4.i4.299. PMID: 25540738; PMCID: PMC4274599. 6: Putra M, Sharma S, Gage M, Gasser G, Hinojo-Perez A, Olson A, Gregory-Flores A, Puttachary S, Wang C, Anantharam V, Thippeswamy T. Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model. Neurobiol Dis. 2020 Jan;133:104443. doi: 10.1016/j.nbd.2019.03.031. Epub 2019 Mar 30. PMID: 30940499; PMCID: PMC6768773. 7: Vasanthi SS, Rao NS, Samidurai M, Massey N, Meyer C, Gage M, Kharate M, Almanza A, Wachter L, Mafuta C, Trevino L, Carlo AM, Bryant E, Corson BE, Wohlgemuth M, Ostrander M, Wang C, Thippeswamy T. Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy. Res Sq [Preprint]. 2023 May 8:rs.3.rs-2883247. doi: 10.21203/rs.3.rs-2883247/v1. Update in: J Neuroinflammation. 2023 Jul 12;20(1):163. doi: 10.1186/s12974-023-02847-1. PMID: 37214912; PMCID: PMC10197763. 8: Schnichels S, Joachim SC. The inducible nitric oxide synthase-inhibitor 1400W as a potential treatment for retinal diseases. Neural Regen Res. 2021 Jun;16(6):1221-1222. doi: 10.4103/1673-5374.300445. PMID: 33269785; PMCID: PMC8224120. 9: Gao Y, Zhou S, Xu Y, Sheng S, Qian SY, Huo X. Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer. Nitric Oxide. 2019 Feb 1;83:33-39. doi: 10.1016/j.niox.2018.12.008. Epub 2018 Dec 24. PMID: 30590117; PMCID: PMC6677402. 10: Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63. doi: 10.1074/jbc.272.8.4959. PMID: 9030556.