Ibuzatrelvir, also named as PF-07817883, is a second-generation, orally bioavailable, SARS-CoV-2 main protease inhibitor with improved metabolic stability versus nirmatrelvir, the antiviral component of the ritonavir boosted therapy Paxlovid. PF-07817883 also demonstrated oral efficacy in a mouse-adapted SARS-CoV-2 model at plasma concentrations equivalent to nirmatrelvir. The preclinical in vivo pharmacokinetics and metabolism studies in human matrices are suggestive of improved oral pharmacokinetics for PF-07817883 in humans, relative to nirmatrelvir. In vitro inhibition/induction studies against major human drug metabolizing enzymes/transporters suggest a low potential for perpetrator drug−drug interactions upon single-agent use of PF-07817883.
MedKoo Cat#: 140265
Name: Ibuzatrelvir
CAS#: 2755812-39-4
Chemical Formula: C21H30F3N5O5
Exact Mass: 489.2199
Molecular Weight: 489.50
Elemental Analysis: C, 51.53; H, 6.18; F, 11.64; N, 14.31; O, 16.34
The following data is based on the product molecular weight 489.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |