MedKoo Cat#: 558113 | Name: Karounidiol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Karounidiol is a bioactive chemical with cytotoxic activity.

Chemical Structure

Karounidiol
Karounidiol
CAS#118117-31-0

Theoretical Analysis

MedKoo Cat#: 558113

Name: Karounidiol

CAS#: 118117-31-0

Chemical Formula: C30H48O2

Exact Mass: 440.3700

Molecular Weight: 440.71

Elemental Analysis: C, 81.76; H, 10.98; O, 7.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CCRIS7117; CCRIS-7117; CCRIS 7117;
IUPAC/Chemical Name
(3R,4aR,6bS,8aS,11R,12aR,12bS,14bR)-11-(hydroxymethyl)-4,4,6b,8a,11,12b,14b-heptamethyl-1,2,3,4,4a,5,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicen-3-ol
InChi Key
UIXJVDGAGQPTFR-HJOMSTLHSA-N
InChi Code
InChI=1S/C30H48O2/c1-25(2)22-9-8-21-20(28(22,5)12-11-24(25)32)10-13-30(7)23-18-26(3,19-31)14-15-27(23,4)16-17-29(21,30)6/h8,10,22-24,31-32H,9,11-19H2,1-7H3/t22-,23+,24+,26+,27+,28-,29+,30-/m0/s1
SMILES Code
OC[C@@](CC1)(C)C[C@@H]2[C@@]1(C)CC[C@@]3(C)[C@@]2(C)CC=C4C3=CC[C@H]5C(C)(C)[C@H](O)CC[C@@]45C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yasukawa K, Akihisa T, Tamura T, Takido M. Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Biol Pharm Bull. 1994 Mar;17(3):460-2. PubMed PMID: 8019519. 2: Akihisa T, Tokuda H, Ichiishi E, Mukainaka T, Toriumi M, Ukiya M, Yasukawa K, Nishino H. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 2001 Nov 8;173(1):9-14. PubMed PMID: 11578803. 3: Akihisa T, Kokke WC, Tamura T, Nambara T. 7-Oxodihydrokarounidiol [7-oxo-D:C-friedo-olean-8-ene-3 alpha,29-diol], a novel triterpene from Trichosanthes kirilowii. Chem Pharm Bull (Tokyo). 1992 May;40(5):1199-202. PubMed PMID: 1394634. 4: Wu XY, Chao ZM, Wang C, Tan ZG, Sun W. [Chemical constituents contained in fatty oil from seeds of Cucumis sativus]. Zhongguo Zhong Yao Za Zhi. 2012 Nov;37(21):3252-5. Chinese. PubMed PMID: 23397724. 5: Ukiya M, Akihisa T, Tokuda H, Toriumi M, Mukainaka T, Banno N, Kimura Y, Hasegawa J, Nishino H. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate. J Agric Food Chem. 2002 Nov 6;50(23):6710-5. PubMed PMID: 12405766. 6: Xi YB, Chao ZM, Wang J. [Chemical constituents in unsaponifiable matter from seeds of Trichosanthes hupehensis]. Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(21):2262-5. Chinese. PubMed PMID: 18309669. 7: Akihisa T, Ogihara J, Kato J, Yasukawa K, Ukiya M, Yamanouchi S, Oishi K. Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase. Lipids. 2001 May;36(5):507-12. PubMed PMID: 11432464. 8: Kan LD, Hu Q, Chao ZM, Song X, Cao XL. [Chemical constituents of unsaponifiable matter from seed oil of Momordica cochinchinensis]. Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(17):1441-4. Chinese. PubMed PMID: 17087086.