Synonym
V7MB1GM2IM; (2S,6S)-Hnk; (2S,6S)-Hydroxynorketamine; Hydroxynorketamine, (2S,6S)-; 95342-35-1
IUPAC/Chemical Name
2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-one
InChi Key
CFBVGSWSOJBYGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H14ClNO2/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16/h1-2,4-5,10,15H,3,6-7,14H2
SMILES Code
C1CC(C(=O)C(C1)(C2=CC=CC=C2Cl)N)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
239.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kang H, Park P, Han M, Tidball P, Georgiou J, Bortolotto ZA, Lodge D, Kaang
BK, Collingridge GL. (2S,6S)- and
(2R,6R)-hydroxynorketamine inhibit the induction of NMDA receptor-
dependent LTP at hippocampal CA1 synapses in mice. Brain Neurosci Adv. 2020 Sep
28;4:2398212820957847. doi: 10.1177/2398212820957847. PMID: 33088919; PMCID:
PMC7545754.
2: Lilius TO, Viisanen H, Jokinen V, Niemi M, Kalso EA, Rauhala PV. Interactions
of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine,
with Morphine. Basic Clin Pharmacol Toxicol. 2018 May;122(5):481-488. doi:
10.1111/bcpt.12941. Epub 2017 Dec 27. PMID: 29171155.
3: Chen BK, Luna VM, LaGamma CT, Xu X, Deng SX, Suckow RF, Cooper TB, Shah A,
Brachman RA, Mendez-David I, David DJ, Gardier AM, Landry DW, Denny CA. Sex-
specific neurobiological actions of prophylactic (R,S)-ketamine,
(2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine.
Neuropsychopharmacology. 2020 Aug;45(9):1545-1556. doi:
10.1038/s41386-020-0714-z. Epub 2020 May 17. PMID: 32417852; PMCID: PMC7360766.
