Zharp-99- is a PIPK3 inhibitor. Zharp-99 is able to directly bind RIPK3 (KD = 1.35 nM) and block its kinase activity (IC50 < 1 μM by ADP-Glo) and has no impact on RIPK1 kinase activity at 10 μM.
MedKoo Cat#: 122754
Name: Zharp-99
CAS#: N/A
Chemical Formula: C21H16ClN3O2S2
Exact Mass: 441.0400
Molecular Weight: 441.95
Elemental Analysis: C, 57.07; H, 3.65; Cl, 8.02; N, 9.51; O, 7.24; S, 14.51
The following data is based on the product molecular weight 441.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
