GW-328267 | CAS#210237-78-8 |

MedKoo Cat#: 596034 | Name: GW-328267

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW-328267 is an adenosine A2 receptor agonist.

Chemical Structure

GW-328267

CAS#210237-78-8

Theoretical Analysis

MedKoo Cat#: 596034

Name: GW-328267

CAS#: 210237-78-8

Chemical Formula: C21H26N10O4

Exact Mass: 482.2138

Molecular Weight: 482.50

Elemental Analysis: C, 52.28; H, 5.43; N, 29.03; O, 13.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GW-328267; GW328267; GW 328267; J2.047.755E; GW328267X;

IUPAC/Chemical Name

(2R,3R,4S,5R)-2-(6-amino-2-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

InChi Key

FLBKPDIBGNWXMT-NIQZGXKPSA-N

InChi Code

InChI=1S/C21H26N10O4/c1-2-31-28-18(27-29-31)16-14(33)15(34)20(35-16)30-10-23-13-17(22)25-21(26-19(13)30)24-12(9-32)8-11-6-4-3-5-7-11/h3-7,10,12,14-16,20,32-34H,2,8-9H2,1H3,(H3,22,24,25,26)/t12-,14-,15+,16-,20+/m0/s1

SMILES Code

O[C@H]1[C@H](N2C=NC3=C(N)N=C(N[C@H](CO)CC4=CC=CC=C4)N=C23)O[C@H](C5=NN(CC)N=N5)[C@H]1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 482.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA. The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L259-71. doi: 10.1152/ajplung.00395.2011. Epub 2012 Jun 1. PubMed PMID: 22659881. 2: Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Walker DK, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Lemaitre A, Wright KN, Whitlock L, Stuart EF, Wright PA, Macintyre F. SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4471-5. doi: 10.1016/j.bmcl.2009.05.027. Epub 2009 May 12. PubMed PMID: 19501510.