Ofloxacin-d8 is intended for use as an internal standard for the quantification of ofloxacin by GC- or LC-MS. Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that prevents supercoiling of bacterial chromosomes by DNA gyrase. It is active against Gram-positive and Gram-negative bacteria with MIC90s ranging from 0.39 to 3.13 μg/ml for clinical isolates of S. aureus, S. epidermidis, S. pyogenes, and S. faecalis and ≤0.78 μg/ml for N. gonorrhoeae and various species of Enterobacteriaceae. Ofloxacin is active in vivo, with ED50 values ranging from 0.7 to 75.1 mg/kg in infected mice. Formulations containing ofloxacin have been used to treat urinary tract infections, gonorrhea, prostatitis, and gastroenteritis.
MedKoo Cat#: 464182
Name: Ofloxacin-d8 HCl
CAS#: unknown
Chemical Formula: C18H13D8ClFN3O4
Exact Mass: 405.1707
Molecular Weight: 405.88
Elemental Analysis: C, 53.27; H, 7.20; Cl, 8.73; F, 4.68; N, 10.35; O, 15.77
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| To be determined | 0.0 | 100.00 |
The following data is based on the product molecular weight 405.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
