Pimicotinib (ABSK021) is an orally bioavailable, highly selective small-molecule inhibitor of colony-stimulating factor 1 receptor (CSF1R), exhibiting potent in vitro activity with an IC₅₀ of less than 30 nM. It demonstrates over 40-fold selectivity against related kinases such as c-KIT, FLT3, PDGFR, and VEGFR2, indicating a strong specificity for CSF1R. In silico docking studies further support its binding affinity, with a docking score of −9.45 kcal/mol for CSF1R, comparable to other known CSF1R-specific inhibitors.
MedKoo Cat#: 140242
Name: Pimicotinib free base
CAS#: 2253123-16-7 (free base)
Chemical Formula: C22H24N6O3
Exact Mass: 420.1910
Molecular Weight: 420.47
Elemental Analysis: C, 62.84; H, 5.75; N, 19.99; O, 11.42
The following data is based on the product molecular weight 420.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
