Tasurgratinib, also known as E-7090, is a fibroblast growth factor receptor inhibitor potentially for the treatment of solid tumors. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3. In kinetic analyses of the interaction between E7090 and FGFR1 tyrosine kinase, E7090 associated more rapidly with FGFR1 than did the type II FGFR1 inhibitor ponatinib, and E7090 dissociated more slowly from FGFR1, with a relatively longer residence time, than did the type I FGFR1 inhibitor AZD4547, suggesting that its kinetics are more similar to the type V inhibitors, such as lenvatinib.
MedKoo Cat#: 124475
Name: Tasurgratinib succinate
CAS#: 1879965-80-6 (succinate)
Chemical Formula: C36H43N5O10
Exact Mass: 705.3000
Molecular Weight: 705.77
Elemental Analysis: C, 61.27; H, 6.14; N, 9.92; O, 22.67
The following data is based on the product molecular weight 705.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
-AHPC-benzyl-piperazine HCl4501.jpg "(S,R,S)-AHPC-benzyl-piperazine HCl")
