DX2-201 | CAS#2749554-00-3 | (NDUFS7) Antagonist

MedKoo Cat#: 150012 | Name: DX2-201

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DX2-201 is a NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) antagonist. DX2-201 suppresses the proliferation of a panel of cell lines. In studies, DX2-201 shows synergy with multiple metabolic modulators, select OXPHOS inhibitors, and PARP inhibitors.

Chemical Structure

DX2-201

CAS#2749554-00-3

Theoretical Analysis

MedKoo Cat#: 150012

Name: DX2-201

CAS#: 2749554-00-3

Chemical Formula: C18H28N2O6S2

Exact Mass: 432.1389

Molecular Weight: 432.55

Elemental Analysis: C, 49.98; H, 6.53; N, 6.48; O, 22.19; S, 14.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DX2-201; DX2201; DX2 201;

IUPAC/Chemical Name

Ethyl (3R)-1-[4-(diethylsulfamoyl)phenyl]sulfonylpiperidine-3-carboxylate

InChi Key

YXHKYCUPYONBDS-OAHLLOKOSA-N

InChi Code

1S/C18H28N2O6S2/c1-4-19(5-2)27(22,23)16-9-11-17(12-10-16)28(24,25)20-13-7-8-15(14-20)18(21)26-6-3/h9-12,15H,4-8,13-14H2,1-3H3/t15-/m1/s1

SMILES Code

O=C([C@H]1CN(S(=O)(C2=CC=C(S(=O)(N(CC)CC)=O)C=C2)=O)CCC1)OCC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 432.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xu Y, Xue D, Kyani A, Bankhead A 3rd, Roy J, Ljungman M, Neamati N. First-in- Class NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) Antagonist for the Treatment of Pancreatic Cancer. ACS Pharmacol Transl Sci. 2023 Jun 28;6(8):1164-1181. doi: 10.1021/acsptsci.3c00069. PMID: 37588763; PMCID: PMC10425995. 2: Xue D, Xu Y, Kyani A, Roy J, Dai L, Sun D, Neamati N. Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors. J Med Chem. 2022 Jan 13;65(1):343-368. doi: 10.1021/acs.jmedchem.1c01509. Epub 2022 Jan 4. PMID: 34982568; PMCID: PMC9164994.