Skp2 inhibitor 1 (compound 14i), also known as MUN12631, is a potent and selective Skp2 inhibitor. This compound was first reported as compound 14i in Journal of Medicinal Chemistry (2023), 66(11), 7221-7242. compound 14i shows potent activity against the Skp2−Cks1 interaction with an IC50 value of 2.8 μM and against PC-3 and MGC-803 cells with IC50 values of 4.8 and 7.0 μM, respectively. Most importantly, compound 14i exhibited effectively anticancer effects on PC-3 and MGC-803 xenograft mice models without obvious toxicity. It may be named as MUN12631 according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).
MedKoo Cat#: 124393
Name: Skp2 inhibitor 1
CAS#: 2760612-63-1
Chemical Formula: C23H23ClN4O
Exact Mass: 406.1560
Molecular Weight: 406.91
Elemental Analysis: C, 67.89; H, 5.70; Cl, 8.71; N, 13.77; O, 3.93
The following data is based on the product molecular weight 406.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
