MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 558638 | Name: Perfluorobutyric acid
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perfluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides.

Chemical Structure

Perfluorobutyric acid
CAS#375-22-4

Theoretical Analysis

MedKoo Cat#: 558638

Name: Perfluorobutyric acid

CAS#: 375-22-4

Chemical Formula: C4HF7O2

Exact Mass: 213.9865

Molecular Weight: 214.04

Elemental Analysis: C, 22.45; H, 0.47; F, 62.13; O, 14.95

Price and Availability

Size Price Availability Quantity
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Perfluorobutyric acid; Perfluoropropanecarboxylic acid; Heptafluorobutyric acid; Kyselina heptafluormaselna;
IUPAC/Chemical Name
Butanoic acid, 2,2,3,3,4,4,4-heptafluoro-
InChi Key
YPJUNDFVDDCYIH-UHFFFAOYSA-N
InChi Code
InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13)
SMILES Code
O=C(O)C(F)(F)C(F)(F)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Perfluorobutyric acid is an ion pair reagent for reverse-phase HPLC.
In vitro activity:
In this study, wastewater containing different concentrations of perfluorooctanoic acid (PFOA)/perfluorobutyric acid (PFBA) was treated in constructed rapid infiltration systems with coke as filler. The addition of 5 and 10 mg/L PFOA inhibited the removal of chemical oxygen demand (COD) (80.42%, 89.27%), ammonia nitrogen (31.32%, 41.14%), and total phosphorus (TP) (43.30%, 39.34%). Meanwhile, 10 mg/L PFBA inhibited TP removal of the systems. Based on X-ray photoelectron spectroscopy, the percentages of F- within the PFOA and PFBA groups were 12.91% and 48.46%, respectively. Reference: Bioresour Technol. 2023 Jun;378:128998. https://pubmed.ncbi.nlm.nih.gov/37011846/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 214.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Li X, Huang X, Fan S, Su C, Ding F, Wen S, Li D, Chen M. Effects of perfluoroalkyl substances on the operational efficiency, microbial communities, and key metabolic pathways of constructed rapid infiltration system with coke as filler layer. Bioresour Technol. 2023 Jun;378:128998. doi: 10.1016/j.biortech.2023.128998. Epub 2023 Apr 1. PMID: 37011846. 2. Thomas J, Serrato A 3rd, Lin W, Jäger W, Xu Y. Perfluorobutyric acid and its monohydrate: a chirped pulse and cavity based fourier transform microwave spectroscopic study. Chemistry. 2014 May 12;20(20):6148-53. doi: 10.1002/chem.201304321. Epub 2014 Apr 22. PMID: 24756992.
In vitro protocol:
1. Li X, Huang X, Fan S, Su C, Ding F, Wen S, Li D, Chen M. Effects of perfluoroalkyl substances on the operational efficiency, microbial communities, and key metabolic pathways of constructed rapid infiltration system with coke as filler layer. Bioresour Technol. 2023 Jun;378:128998. doi: 10.1016/j.biortech.2023.128998. Epub 2023 Apr 1. PMID: 37011846. 2. Thomas J, Serrato A 3rd, Lin W, Jäger W, Xu Y. Perfluorobutyric acid and its monohydrate: a chirped pulse and cavity based fourier transform microwave spectroscopic study. Chemistry. 2014 May 12;20(20):6148-53. doi: 10.1002/chem.201304321. Epub 2014 Apr 22. PMID: 24756992.
In vivo protocol:
TBD
1: Pietropoli E, Bardhi A, Simonato V, Zanella M, Iori S, Barbarossa A, Giantin M, Dacasto M, De Liguoro M, Pauletto M. Comparative toxicity assessment of alternative versus legacy PFAS: Implications for two primary trophic levels in freshwater ecosystems. J Hazard Mater. 2024 Sep 15;477:135269. doi: 10.1016/j.jhazmat.2024.135269. Epub 2024 Jul 20. PMID: 39068881. 2: Lada ZG, Mathioudakis GN, Soto Beobide A, Andrikopoulos KS, Voyiatzis GA. Generic method for the detection of short & long chain PFAS extended to the lowest concentration levels of SERS capability. Chemosphere. 2024 Sep;363:142916. doi: 10.1016/j.chemosphere.2024.142916. Epub 2024 Jul 21. PMID: 39043274. 3: Liu N, Li Y, Zhang M, Che N, Song X, Liu Y, Li C. Efficient adsorption of short-chain perfluoroalkyl substances by pristine and Fe/Cu-loaded reed straw biochars. Sci Total Environ. 2024 Oct 10;946:174223. doi: 10.1016/j.scitotenv.2024.174223. Epub 2024 Jun 23. PMID: 38917893. 4: Lee CS, Venkatesan AK. Cationic surfactant-assisted foam fractionation enhances the removal of short-chain perfluoroalkyl substances from impacted water. Chemosphere. 2024 Aug;362:142614. doi: 10.1016/j.chemosphere.2024.142614. Epub 2024 Jun 13. PMID: 38878978. 5: Zhou WL, Wu YG, Wang S, Zhang R, Wang LH, Liu J, Xu X. Laponite-activated AIE supramolecular assembly with modulating multicolor luminescence for logic digital encryption and perfluorinated pollutant detection. Biosens Bioelectron. 2024 Aug 15;258:116343. doi: 10.1016/j.bios.2024.116343. Epub 2024 May 6. PMID: 38718636. 6: Zhao M, Yin N, Yang R, Li S, Zhang S, Faiola F. Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models. Environ Sci Technol. 2024 May 14;58(19):8215-8227. doi: 10.1021/acs.est.3c10758. Epub 2024 Apr 30. PMID: 38687897. 7: Wang G, Sun J, Li L, Li J, Li P. Perfluorobutanoic acid triggers metabolic and transcriptional reprogramming in wheat seedlings. Sci Total Environ. 2024 Jun 1;927:172343. doi: 10.1016/j.scitotenv.2024.172343. Epub 2024 Apr 10. PMID: 38608890. 8: Mohamed MS, Chaplin BP, Abokifa AA. Adsorption of per- and poly-fluoroalkyl substances (PFAS) on Ni: A DFT investigation. Chemosphere. 2024 Jun;357:141849. doi: 10.1016/j.chemosphere.2024.141849. Epub 2024 Apr 8. PMID: 38599331. 9: Mo L, Wan N, Zhou B, Shao M, Zhang X, Li M, Liu Y, Mai B. Per- and polyfluoroalkyl substances in waterbird feathers around Poyang Lake, China: Compound and species-specific bioaccumulation. Ecotoxicol Environ Saf. 2024 Mar 15;273:116141. doi: 10.1016/j.ecoenv.2024.116141. Epub 2024 Feb 23. PMID: 38394760. 10: Tan K, Zhang Q, Wang Y, Wang C, Hu C, Wang L, Liu H, Tian Z. Associations between per- and polyfluoroalkyl substances exposure and thyroid hormone levels in the elderly. Sci Total Environ. 2024 Apr 10;920:170761. doi: 10.1016/j.scitotenv.2024.170761. Epub 2024 Feb 8. PMID: 38340830. 11: Wang H, Zhang H, Hu S, Xu T, Yang Y, Cao M, Wei S, Song Y, Han J, Yin D. Insight into the differential toxicity of PFOA and PFBA based on a 3D-cultured MDA-MB-231 cell model. J Hazard Mater. 2024 Mar 5;465:133499. doi: 10.1016/j.jhazmat.2024.133499. Epub 2024 Jan 11. PMID: 38219595. 12: Asadi Zeidabadi F, Banayan Esfahani E, Moreira R, McBeath ST, Foster J, Mohseni M. Structural dependence of PFAS oxidation in a boron doped diamond- electrochemical system. Environ Res. 2024 Apr 1;246:118103. doi: 10.1016/j.envres.2024.118103. Epub 2024 Jan 3. PMID: 38181849. 13: Zhao M, Yin N, Yang R, Li S, Zhang S, Faiola F. Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics. Sci Total Environ. 2024 Feb 25;913:169702. doi: 10.1016/j.scitotenv.2023.169702. Epub 2023 Dec 30. PMID: 38163615. 14: Tao Y, Pang Y, Luo M, Jiang X, Huang J, Li Z. Multi-media distribution and risk assessment of per- and polyfluoroalkyl substances in the Huai River Basin, China. Sci Total Environ. 2024 Mar 1;914:169581. doi: 10.1016/j.scitotenv.2023.169581. Epub 2023 Dec 25. PMID: 38151127. 15: Yuan W, Song S, Lu Y, Shi Y, Yang S, Wu Q, Wu Y, Jia D, Sun J. Legacy and alternative per-and polyfluoroalkyl substances (PFASs) in the Bohai Bay Rim: Occurrence, partitioning behavior, risk assessment, and emission scenario analysis. Sci Total Environ. 2024 Feb 20;912:168837. doi: 10.1016/j.scitotenv.2023.168837. Epub 2023 Nov 30. PMID: 38040376. 16: Ivantsova E, Lu A, Martyniuk CJ. Occurrence and toxicity mechanisms of perfluorobutanoic acid (PFBA) and perfluorobutane sulfonic acid (PFBS) in fish. Chemosphere. 2024 Feb;349:140815. doi: 10.1016/j.chemosphere.2023.140815. Epub 2023 Nov 29. PMID: 38040261. 17: Qin XD, Zhou Y, Bloom MS, Qian ZM, Geiger SD, Vaughn MG, Chu C, Li QQ, Yang BY, Hu LW, Yu Y, Zeng XW, Dong GH. Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study. Environ Health Perspect. 2023 Nov;131(11):117006. doi: 10.1289/EHP11377. Epub 2023 Nov 14. PMID: 37962440; PMCID: PMC10644897. 18: Li Y, Wang H, Wang M, Wang Y, Shi B. The perfluoroalkyl substances influenced the distribution of bacterial communities and their functions from source water to tap water. Water Res. 2023 Dec 1;247:120831. doi: 10.1016/j.watres.2023.120831. Epub 2023 Nov 5. PMID: 37950955. 19: Ahrens L, Rakovic J, Ekdahl S, Kallenborn R. Environmental distribution of per- and polyfluoroalkyl substances (PFAS) on Svalbard: Local sources and long- range transport to the Arctic. Chemosphere. 2023 Dec;345:140463. doi: 10.1016/j.chemosphere.2023.140463. Epub 2023 Oct 16. PMID: 37852382. 20: Daugherty S, Mulabagal V, Hayworth J, Akingbemi BT. Legacy and Emerging Perfluoroalkyl and Polyfluoroalkyl Substances Regulate Steroidogenesis in the Male Gonad. Endocrinology. 2023 Nov 2;164(12):bqad142. doi: 10.1210/endocr/bqad142. PMID: 37767721.