SB-239272 | p38 MAPK Inhibitor

MedKoo Cat#: 564558 | Name: SB-239272

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB-239272 is an inhibitor of p38 MAPK.

Chemical Structure

SB-239272

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564558

Name: SB-239272

CAS#: NONE

Chemical Formula: C24H22FN5O

Exact Mass: 415.1808

Molecular Weight: 415.47

Elemental Analysis: C, 69.38; H, 5.34; F, 4.57; N, 16.86; O, 3.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SB-239272; SB239272; SB 239272

IUPAC/Chemical Name

4-[5-(4-Fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-phenoxypyrimidine

InChi Key

MLNSFBMGRWGGII-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H22FN5O/c25-18-8-6-17(7-9-18)22-23(30(16-28-22)19-10-13-26-14-11-19)21-12-15-27-24(29-21)31-20-4-2-1-3-5-20/h1-9,12,15-16,19,26H,10-11,13-14H2

SMILES Code

FC1=CC=C(C2=C(C3=NC(OC4=CC=CC=C4)=NC=C3)N(C5CCNCC5)C=N2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ravindra GK, Achaiah G, Sastry GN. Molecular modeling studies of phenoxypyrimidinyl imidazoles as p38 kinase inhibitors using QSAR and docking. Eur J Med Chem. 2008 Apr;43(4):830-8. Epub 2007 Jul 6. PubMed PMID: 17706839.