HG-106 is a potent SLC7A11 inhibitor. HG-106 markedly decreased cystine uptake and intracellular glutathione biosynthesis. Furthermore, HG106 exhibited selective cytotoxicity toward KRAS-mutant cells by increasing oxidative stress- and ER stress-mediated cell apoptosis. Of note, treatment of KRAS-mutant LUAD with HG-106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival.
MedKoo Cat#: 124082
Name: HG-106
CAS#: 928712-10-1
Chemical Formula: C15H13ClN4O2
Exact Mass: 316.0727
Molecular Weight: 316.75
Elemental Analysis: C, 56.88; H, 4.14; Cl, 11.19; N, 17.69; O, 10.10
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 125.0 | 394.65 |
The following data is based on the product molecular weight 316.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
