Synonym
Glipentide; Glisentide; Staticum; UR-661; UR 661; UR661;
IUPAC/Chemical Name
N-[2-[4-(Cyclopentylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
InChi Key
NSJYMFYVNWVGON-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H27N3O5S/c1-30-20-9-5-4-8-19(20)21(26)23-15-14-16-10-12-18(13-11-16)31(28,29)25-22(27)24-17-6-2-3-7-17/h4-5,8-13,17H,2-3,6-7,14-15H2,1H3,(H,23,26)(H2,24,25,27)
SMILES Code
O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCC2)=O)=O)C=C1)C3=CC=CC=C3OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
445.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Gómez PL, Planas JM, Moretó M, Bolufer J. Effect of glipentide on galactose absorption and disaccharidase activity in rat small intestine. Rev Esp Fisiol. 1980 Dec;36(4):445-8. PubMed PMID: 7221166.
7: Chanal JL, Calmette MT, Khiat M, Rimbau V, Vera A. Pharmacokinetics and metabolism of 14C-glipentide, a new antidiabetic, after oral and intravenous administration. Arzneimittelforschung. 1977;27(4):852-6. PubMed PMID: 577463.
8: Moncada Lorenzo E, Garcia RV, Barberia Layana JJ, Morant Ciscard JA, Calleja Canelas A. Clinical comparison between glipentide (Staticum) and glibenclamide in diabetics. Curr Ther Res Clin Exp. 1977 Jan;21(1):50-7. PubMed PMID: 401712.
9: Rimbau Barreras V, Uriach Marsal J, Pou Torelló JM. [Pharmacokinetic of glipentide (UR-661) by IV. administration on healthy and diabetic volunteers (author's transl)]. Arch Farmacol Toxicol. 1976 Aug;2(2):115-22. Spanish. PubMed PMID: 791156.
10: Herrera E. Effects of sulfonylureas (tolbutamide, glipentide and glibenclamide) on in vitro glycerol metabolism in adipose tissue from rats. Life Sci. 1975 Feb 15;16(4):645-50. PubMed PMID: 1123965.
11: Sánchez-Casals MS, Morell-Mestre J. [Inotropic effect of tolbutamide and glipentide in isolated guinea pig atria (author's transl)]. Rev Esp Fisiol. 1974 Dec;30(4):273-6. Spanish. PubMed PMID: 4456482.
12: HOPKINS BJ, BAXTER RC, TUTTLE LW. THE RETENTION OF STRONTIUM-90 BY FETAL AND NEWBORN RATS. UR-661. UR Rep. 1965 Mar 29;51:1-14. PubMed PMID: 14291904.
13: BENSON RC, INMAN VT. Brachialgia statica dysesthetica in pregnancy. West J Surg Obstet Gynecol. 1956 Mar;64(3):115-29; discussion, 129-30. PubMed PMID: 13299941.
