Synonym
Wighteone; 51225-30-0; Erythrinin B; 6-Isopentenylgenistein
IUPAC/Chemical Name
5,7-dihydroxy-3-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChi Key
KIMDVVKVNNSHGZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18O5/c1-11(2)3-8-14-16(22)9-17-18(19(14)23)20(24)15(10-25-17)12-4-6-13(21)7-5-12/h3-7,9-10,21-23H,8H2,1-2H3
SMILES Code
OC1=C(C2=O)C(OC=C2C3=CC=C(C=C3)O)=CC(O)=C1C/C=C(C)/C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
338.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sun P, Qu Y, Wang Y, Wang J, Wang X, Sheng J. Wighteone exhibits an antitumor
effect against EGFR L858R/T790M mutation non-small cell lung cancer. J Cancer.
2021 May 5;12(13):3900-3908. doi: 10.7150/jca.54574. PMID: 34093797; PMCID:
PMC8176237.
2: Cao ZW, Zeng Q, Pei HJ, Ren LD, Bai HZ, Na RN. HSP90 expression and its
association with wighteone metabolite response in HER2-positive breast cancer
cells. Oncol Lett. 2016 Jun;11(6):3719-3722. doi: 10.3892/ol.2016.4488. Epub
2016 Apr 21. PMID: 27313682; PMCID: PMC4888280.
3: Liu J, Jiang W, Xia Y, Wang X, Shen G, Pang Y. Genistein-Specific G6DT Gene
for the Inducible Production of Wighteone in Lotus japonicus. Plant Cell
Physiol. 2018 Jan 1;59(1):128-141. doi: 10.1093/pcp/pcx167. PMID: 29140457.
4: Yin H, Zhao Y, Zhang Y, Zhang H, Xu L, Zou Z, Yang W, Cheng J, Zhou Y.
Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in
response to treatment with the plant isoflavone, wighteone, as a potential
antifungal agent. Biotechnol Lett. 2006 Jan;28(2):99-105. doi:
10.1007/s10529-005-4954-0. PMID: 16369693.
