ICI 154129 | CAS#83420-94-4 | delta-opiate antagonist

MedKoo Cat#: 597441 | Name: ICI 154129

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI 154129 is a delta-opiate antagonist.

Chemical Structure

ICI 154129

CAS#83420-94-4

Theoretical Analysis

MedKoo Cat#: 597441

Name: ICI 154129

CAS#: 83420-94-4

Chemical Formula: C34H46N4O6S

Exact Mass: 638.3138

Molecular Weight: 638.82

Elemental Analysis: C, 63.93; H, 7.26; N, 8.77; O, 15.03; S, 5.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ICI 154129; ICI154129; ICI-154129; M-154,129; M 154,129; M154,129;

IUPAC/Chemical Name

((S)-2-((2-((S)-N-(2-amino-2-oxoethyl)-2-(diallylamino)-3-(4-hydroxyphenyl)propanamido)ethyl)thio)-3-phenylpropanoyl)-L-leucine

InChi Key

IBOCNUAKKBAFSE-DTXPUJKBSA-N

InChi Code

InChI=1S/C34H46N4O6S/c1-5-16-37(17-6-2)29(21-26-12-14-27(39)15-13-26)33(42)38(23-31(35)40)18-19-45-30(22-25-10-8-7-9-11-25)32(41)36-28(34(43)44)20-24(3)4/h5-15,24,28-30,39H,1-2,16-23H2,3-4H3,(H2,35,40)(H,36,41)(H,43,44)/t28-,29-,30-/m0/s1

SMILES Code

O=C(N)CN(C([C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)=O)CCS[C@@H](CC2=CC=CC=C2)C(N[C@H](C(O)=O)CC(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 638.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Volterra A, Brunello N, Cagiano R, Cuomo V, Racagni G. Behavioural and biochemical effects in C57BL/6J mice after a prolonged treatment with the delta-opiate antagonist ICI 154129. J Pharm Pharmacol. 1984 Dec;36(12):849-51. PubMed PMID: 6151983. 2: Priestley T, Turnbull MJ, Wei E. In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor. Neuropharmacology. 1985 Feb;24(2):107-10. PubMed PMID: 2986029. 3: Benton D, Dalrymple-Alford JC, McAllister KH, Brain PF, Brain S. Comparison in the mouse of the effect of the opiate delta receptor antagonist ICI 154129 and naloxone in tests of extinction, passive avoidance and food intake. Psychopharmacology (Berl). 1984;82(1-2):41-5. PubMed PMID: 6320249. 4: Appelmans N, Carroll JA, Rance MJ, Simon EJ, Traynor JR. Sodium ions increase the binding of the antagonist peptide ICI 174864 to the delta-opiate receptor. Neuropeptides. 1986 Feb-Mar;7(2):139-43. PubMed PMID: 3010168. 5: Suh HH, Tseng LF. Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342(1):67-71. PubMed PMID: 1976234. 6: Leander JD, Gesellchen PD, Mendelsohn LG. Opioid antinociceptive effects of delta-receptor antagonists. Pharmacol Biochem Behav. 1988 Feb;29(2):351-5. PubMed PMID: 2834753. 7: Cooper SJ, Barber DJ, Barbour-McMullen J. Selective attenuation of sweetened milk consumption by opiate receptor antagonists in male and female rats of the Roman strains. Neuropeptides. 1985 Feb;5(4-6):349-52. PubMed PMID: 2987736. 8: Laorden ML, Carrillo E, Puig MM. Prevention of hyperthermia-induced convulsions in immature rat by MR-2266, a kappa antagonist. Methods Find Exp Clin Pharmacol. 1991 Nov;13(9):605-8. PubMed PMID: 1686291. 9: Carter DA, Lightman SL. Opioid control of oxytocin secretion: evidence of distinct regulatory actions of two opiate receptor types. Life Sci. 1987 Jun 8;40(23):2289-96. PubMed PMID: 3035309. 10: Benoliel JJ, Mauborgne A, Bourgoin S, Legrand JC, Hamon M, Cesselin F. Opioid control of the in vitro release of cholecystokinin-like material from the rat substantia nigra. J Neurochem. 1992 Mar;58(3):916-22. PubMed PMID: 1310726. 11: Yilmaz B, Gilmore DP. Delta opioid modulation of hypothalamic serotonergic neurotransmission in the ovariectomized and steroid-primed rat. Neuro Endocrinol Lett. 2000;21(2):115-120. PubMed PMID: 11455339. 12: Panerai AE, Petraglia F, Sacerdote P, Genazzani AR. Mainly mu-opiate receptors are involved in luteinizing hormone and prolactin secretion. Endocrinology. 1985 Sep;117(3):1096-9. PubMed PMID: 2990867. 13: Cowan A, Gmerek DE. In vivo studies with ICI 154,129, a putative delta receptor antagonist. Life Sci. 1982 Nov 15-22;31(20-21):2213-6. PubMed PMID: 6298518. 14: Benton D, Brain S, Brain PF. Comparison of the influence of the opiate delta receptor antagonist, ICI 154,129, and naloxone on social interaction and behaviour in an open field. Neuropharmacology. 1984 Jan;23(1):13-7. PubMed PMID: 6325983. 15: Kirby GC, McQueen DS. Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo. Br J Pharmacol. 1986 Aug;88(4):889-98. PubMed PMID: 2874862; PubMed Central PMCID: PMC1917060. 16: Long JB, Petras JM, Holaday JW. Neurologic deficits and neuronal injury in rats resulting from nonopioid actions of the delta opioid receptor antagonist ICI 174864. J Pharmacol Exp Ther. 1988 Mar;244(3):1169-77. PubMed PMID: 2908046. 17: Benoliel JJ, Collin E, Mauborgne A, Bourgoin S, Legrand JC, Hamon M, Cesselin F. Mu and delta opioid receptors mediate opposite modulations by morphine of the spinal release of cholecystokinin-like material. Brain Res. 1994 Aug 8;653(1-2):81-91. PubMed PMID: 7982079. 18: Smith CF, Rance MJ. Opiate receptors in the rat vas deferens. Life Sci. 1983;33 Suppl 1:327-30. PubMed PMID: 6319887. 19: Jørgensen HA, Hole K. Evidence from behavioural and in vitro receptor binding studies that the enkephalinergic system does not mediate acute ethanol effects. Eur J Pharmacol. 1986 Jun 17;125(2):249-56. PubMed PMID: 3017727. 20: Kiang JG, Wei ET. Inhibition of an opioid-evoked vagal reflex in rats by naloxone, SMS 201-995 and ICI 154, 129. Regul Pept. 1983 Jul;6(3):255-62. PubMed PMID: 6137865.